4-(4-Ethylpiperazin-1-yl)-phenylboronicacidpinacolester

Base Information

• Chemical Name: 4-(4-Ethylpiperazin-1-yl)-phenylboronicacidpinacolester
• CAS No.: 656257-45-3
• Molecular Formula: C18H29BN2O2
• Molecular Weight: 316.251
• Hs Code.: 2934999090
• Mol file: 656257-45-3.mol

Synonyms:W7683;

Chemical Property of 4-(4-Ethylpiperazin-1-yl)-phenylboronicacidpinacolester

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 469.717oC at 760 mmHg
• Flash Point: 237.876oC
• PSA: 24.94000
• Density: 1.1g/cm3
• LogP: 2.13060
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-Ethyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 1-Ethyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine

Technology Process of 4-(4-Ethylpiperazin-1-yl)-phenylboronicacidpinacolester

There total 5 articles about 4-(4-Ethylpiperazin-1-yl)-phenylboronicacidpinacolester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.48%

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) + 1-(4-bromophenyl)-4-ethylpiperazine (656257-43-1) → 1-ethyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine (656257-45-3)

Guidance literature:

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; for 12h; Heating / reflux;

Reference yield:

bis(pinacol)diborane (73183-34-3) + 1-(4-bromophenyl)-4-ethylpiperazine (656257-43-1) → 1-ethyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine (656257-45-3)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; Reflux;

Reference yield:

1,4-bromoiodobenzene (589-87-7) → 1-ethyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine (656257-45-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium phosphate; copper(l) iodide / isopropyl alcohol; ethylene glycol / 48 h / Inert atmosphere; Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: -78 - 20 °C

With potassium phosphate; copper(l) iodide; n-butyllithium; In tetrahydrofuran; hexane; ethylene glycol; isopropyl alcohol;

upstream raw materials:

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

1-(4-bromophenyl)-4-ethylpiperazine

1,4-bromoiodobenzene

4-ethylpiperazine

Downstream raw materials:

(1R,2S)-2-(3-(4-(4-ethylpiperazin-1-yl)phenyl)-1H-indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one

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