2-(Tetrahydro-2H-pyran-4-yl)acetaldehyde

Base Information

Chemical Name:2-(Tetrahydro-2H-pyran-4-yl)acetaldehyde
CAS No.:65626-23-5
Molecular Formula:C7H12O2
Molecular Weight:128.171
Hs Code.:2932999099
European Community (EC) Number:825-299-2
DSSTox Substance ID:DTXSID60590790
Nikkaji Number:J2.877.014F
Wikidata:Q82484428
Mol file:65626-23-5.mol

Synonyms:65626-23-5;2-(Tetrahydro-2H-pyran-4-yl)acetaldehyde;2-(oxan-4-yl)acetaldehyde;(Tetrahydro-pyran-4-yl)-acetaldehyde;tetrahydropyran-4-ylacetaldehyde;4-TETRAHYDROPYRANYLACETALDEHYDE;Tetrahydropyran-4-yl acetaldehyde;2-Tetrahydropyran-4-ylacetaldehyde;MFCD03425265;2H-Pyran-4-acetaldehyde, tetrahydro-;Tetrahydropyranyl-4-acetaldehyde;(Oxan-4-yl)acetaldehyde;4-formylmethyltetrahydropyran;SCHEMBL153266;(4-tetrahydropyranyl)acetaldehyde;DTXSID60590790;AUCJQPPZTFKDHI-UHFFFAOYSA-N;(tetrahydropyran-4-yl)acetaldehyde;AKOS013153471;GS-5572;PB20812;AM101094;DB-073642;CS-0045714;EN300-155986;(tetrahydro-pyran-4-yl)-acetaldehyde, AldrichCPR;A848159;Z1178491139;4-Tetrahydropyranylacetaldehyde

Suppliers and Price of 2-(Tetrahydro-2H-pyran-4-yl)acetaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(Tetrahydro-2H-pyran-4-yl)acetaldehyde
50mg
$ 45.00

SynQuest Laboratories
2-(Oxan-4-yl)acetaldehyde 95%
1 g
$ 208.00

SynQuest Laboratories
2-(Oxan-4-yl)acetaldehyde 95%
10 g
$ 1048.00

SynQuest Laboratories
2-(Oxan-4-yl)acetaldehyde 95%
5 g
$ 640.00

Matrix Scientific
Tetrahydropyran-4-ylacetaldehyde 95+%
1g
$ 594.00

J&W Pharmlab
(Tetrahydro-pyran-4-yl)-acetaldehyde 97%
25g
$ 1192.00

J&W Pharmlab
(Tetrahydro-pyran-4-yl)-acetaldehyde 97%
1g
$ 88.00

Crysdot
2-(Tetrahydro-2H-pyran-4-yl)acetaldehyde 95+%
5g
$ 376.00

Chemenu
Tetrahydropyran-4-ylacetaldehyde 95%
10g
$ 744.00

Chemenu
Tetrahydropyran-4-ylacetaldehyde 95%
5g
$ 458.00

Total 37 raw suppliers

Chemical Property of 2-(Tetrahydro-2H-pyran-4-yl)acetaldehyde

Chemical Property:

Vapor Pressure:0.247mmHg at 25°C
Boiling Point:205.7oC at 760 mmHg
Flash Point:81.6oC
PSA：26.30000
Density:0.968g/cm3
LogP:1.00200
Storage Temp.:Inert atmosphere,Store in freezer, under -20°C
XLogP3:0.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:128.083729621
Heavy Atom Count:9
Complexity:84.9

Purity/Quality:

99%, ^*data from raw suppliers

2-(Tetrahydro-2H-pyran-4-yl)acetaldehyde ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22-37/38-41
Safety Statements: 26-39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COCCC1CC=O

Technology Process of 2-(Tetrahydro-2H-pyran-4-yl)acetaldehyde

There total 5 articles about 2-(Tetrahydro-2H-pyran-4-yl)acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 4677-18-3
2-(tetrahydropyran-4-yl)-ethanol

: 65626-23-5
2-(tetrahydro-2H-pyran-4-yl)acetaldehyde

Guidance literature:: 2-(tetrahydropyran-4-yl)-ethanol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.75h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 - 20 ℃; for 1.33333h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.8b00862

Reference yield:

: 29943-42-8,143562-54-3
Tetrahydro-4H-pyran-4-one

: 65626-23-5
2-(tetrahydro-2H-pyran-4-yl)acetaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / NaH / tetrahydrofuran / 6 h / 20 °C

2: 100 percent / H₂ / Pd/C / methanol / 4 h

3: 67 percent / LiAlH₄ / tetrahydrofuran / 4 h

4: 78 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 2 h / -60 - 20 °C

With lithium aluminium tetrahydride; oxalyl dichloride; hydrogen; sodium hydride; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; 1: Wittig reaction / 4: Swern oxidation;
DOI:10.1016/j.bmc.2005.09.002

Reference yield:

: 130312-00-4
ethyl tetrahydro-4H-pyran-4-ylideneacetate

: 65626-23-5
2-(tetrahydro-2H-pyran-4-yl)acetaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / Pd/C / methanol / 4 h

2: 67 percent / LiAlH₄ / tetrahydrofuran / 4 h

3: 78 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 2 h / -60 - 20 °C

With lithium aluminium tetrahydride; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; 3: Swern oxidation;
DOI:10.1016/j.bmc.2005.09.002