4677-18-3

Basic information

• Product Name: 2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL
• Synonyms: 2-TETRAHYDRO-2H-PYRAN-4-YLETHANOL;2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL;4-(2-Hydroxyethyl)tetrahydro-2H-pyran 97%;(4-HYDROXYETHYL)TETRAHYDROPYRAN;4-(2-Hydroxyethyl)tetrahydro-2H-pyran;2-(Tetrahydro-2H-pyran-4-yl)ethan-1-ol, 4-(2-Hydroxyethyl)oxane;4-(2-Hydroxyethyl)tetrahydropyran;Tetrahydro-2H-pyran-4-ethanol
• CAS NO: 4677-18-3
• Molecular Formula: C₇H₁₄O₂
• Molecular Weight: 130.18
• Product Categories: Hydroxymethyl's;Pyrans, Piperidines &Piperazines;Pyrans, Piperidines & Piperazines
• Mol File: 4677-18-3.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 226℃
• Flash Point: 95℃
• Appearance: /
• Density: 0.981
• Vapor Pressure: 0.017mmHg at 25°C
• Refractive Index: 1.449
• Storage Temp.: 2-8°C
• PKA: 15.06±0.10(Predicted)
• CAS DataBase Reference: 2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL(4677-18-3)
• EPA Substance Registry System: 2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL(4677-18-3)

Safety Data

• Hazard Codes: Xi
• Statements: 10-21/22-36/37/38-41-37/38
• Safety Statements: 16-23-26-36/37/39-39
• RIDADR: UN1987
• Hazardous Substances Data: 4677-18-3(Hazardous Substances Data)

Usage

General Description

2-(Tetrahydro-pyran-4-yl)-ethanol is a chemical compound that contains a tetrahydropyran ring and an ethyl alcohol group. It is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals, agrochemicals, and fine chemicals. The tetrahydropyran moiety is a six-membered cyclic ether, which imparts unique properties to the compound, such as a relatively high boiling point and good solubility in organic solvents. 2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL is also used as a solvent and reagent in chemical reactions, and it has potential applications in the flavor and fragrance industry. Additionally, it has been studied for its potential medicinal properties, such as its antimicrobial and antiparasitic activities.

InChI:InChI=1/C7H14O2/c8-4-1-7-2-5-9-6-3-7/h7-8H,1-6H2

Upstream product

• 85064-61-5 2-(tetrahydro-2H-pyran-4-yl)acetic acid 
• 130312-00-4 ethyl tetrahydro-4H-pyran-4-ylideneacetate 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 57056-39-0 3-carboxymethylglutaric acid 
• 103260-44-2 ethyl tetrahydropyran-4-acetate 

Downstream Products

• 1428129-06-9 4-(2-(2-(bromomethyl)-4-chlorophenoxy)ethyl)tetrahydro-2H-pyran 
• 1428129-08-1 (5-chloro-2-(2-(tetrahydro-2H-pyran-4-yl)ethoxy)phenyl)methanol 
• 1428129-07-0 5-chloro-2-(2-(tetrahydro-2H-pyran-4-yl)ethoxy)benzaldehyde 
• 1312016-63-9 5-methoxy-2-[2-(tetrahydro-pyran-4-yl)-1(R)-(4-trifluoromethyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridine 
• 1312021-10-5 5-methoxy-2-[2-(tetrahydro-pyran-4-yl)-1(S)-(4-trifluoromethyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridine 
• 1312016-59-3 2-[1(R)-(4-methanesulfonyl-phenyl)-2-(tetrahydro-pyran-4-yl)-ethyl]-5-methoxy-1H-pyrrolo[2,3-b]pyridine 
• 1312021-09-2 2-[1(S)-(4-methanesulfonyl-phenyl)-2-(tetrahydro-pyran-4-yl)-ethyl]-5-methoxy-1H-pyrrolo[2,3-b]pyridine 
• 1312018-44-2 1-(1-benzenesulfonyl-5-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-ethanone 
• 1312016-99-1 2-[1(R)-(4-methanesulfonyl-phenyl)-2-(tetrahydro-pyran-4-yl)-ethyl]-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

Aiming to Miss a Moving Target: Bromo and Extra Terminal Domain (BET) Selectivity in Constrained ATAD2 Inhibitors

ATAD2 is a cancer-associated protein whose bromodomain has been described as among the least druggable of its class. In our recent disclosure of the first chemical probe against this bromodomain, GSK8814 (6), we described the use of a conformationally constrained methoxy piperidine to gain selectivity over the BET bromodomains. Here we describe an orthogonal conformational restriction strategy of the piperidine ring to give potent and selective tropane inhibitors and show structural insights into why this was more challenging than expected. Greater understanding of why different rational approaches succeeded or failed should help in the future design of selectivity in the bromodomain family.

ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF

Described herein are compounds of Formula (S-I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.

EP1 RECEPTOR LIGANDS

The present invention belongs to the field of EP1 receptor ligands. More specifically it refers to compounds of general formula (I) having great affinity and selectivity for the EP1 receptor. The invention also refers to the process for their preparation, to their use as medicament for the treatment and/or prophylaxis of diseases or disorders mediated by the EP1 receptor as well as to pharmaceutical compositions comprising them.