1-Pyrrolidinamine, 2-(methoxymethyl)-N-(1-methylethylidene)-, (S)-

Base Information

Chemical Name:1-Pyrrolidinamine, 2-(methoxymethyl)-N-(1-methylethylidene)-, (S)-
CAS No.:65651-52-7
Molecular Formula:C9H18N2O
Molecular Weight:170.255
Hs Code.:
DSSTox Substance ID:DTXSID10451206
Nikkaji Number:J663.709D

Synonyms:65651-52-7;1-Pyrrolidinamine, 2-(methoxymethyl)-N-(1-methylethylidene)-, (S)-;SCHEMBL14000817;DTXSID10451206;(2S)-2alpha-(Methoxymethyl)-N-isopropylidenepyrrolidin-1-amine

Suppliers and Price of 1-Pyrrolidinamine, 2-(methoxymethyl)-N-(1-methylethylidene)-, (S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Pyrrolidinamine, 2-(methoxymethyl)-N-(1-methylethylidene)-, (S)-

Chemical Property:

XLogP3:1.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:170.141913202
Heavy Atom Count:12
Complexity:164

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=NN1CCCC1COC)C
Isomeric SMILES:CC(=NN1CCC[C@H]1COC)C

Technology Process of 1-Pyrrolidinamine, 2-(methoxymethyl)-N-(1-methylethylidene)-, (S)-

There total 1 articles about 1-Pyrrolidinamine, 2-(methoxymethyl)-N-(1-methylethylidene)-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 59983-39-0,187035-29-6
(S)-1-amino-2-(methoxymethyl)pyrrolidine

: 67-64-1
acetone

: 65651-52-7
(S)-(+)-2-methoxymethyl-1-(1-methylethylideneamino)pyrrolidine

Guidance literature:: Ambient temperature;

Reference yield:

: 103-26-4,1754-62-7
Methyl cinnamate

: 65651-52-7
(S)-(+)-2-methoxymethyl-1-(1-methylethylideneamino)pyrrolidine

: 89393-62-4,131905-98-1,131906-33-7,131906-34-8
5-[(Z)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-3-phenyl-hexanoic acid methyl ester

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1.) THF, 0 deg C, 2.) from -78 to 0 deg C, 8.5 h;
DOI:10.1021/jm00107a041

Reference yield:

: 65651-52-7
(S)-(+)-2-methoxymethyl-1-(1-methylethylideneamino)pyrrolidine

: 175430-80-5
(+)-(2S,3'S)-1-<2'-(t-Butyldimethylsilyl)-1'-phenylbut-3'-ylideneamino>-2-methoxymethylpyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / LDA / tetrahydrofuran / 1.) 0 deg C, 4 h, 2.) -78 deg C, 1 h; -78 deg C -> room temp.

2: 83 percent / n-BuLi, diisopropylamine / diethyl ether; hexane / 1.) 0 deg C, 4 h; -78 deg C, 0.5 h, 2.) -78 deg C, 1 h; -78 deg C -> room temp.

With n-butyllithium; diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane;