Benzamide, N-(3-((4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)-, monohydrochloride

Base Information

Chemical Name:Benzamide, N-(3-((4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)-, monohydrochloride
CAS No.:65189-49-3
Molecular Formula:C21H25 N5 O3 . Cl H
Molecular Weight:0
Hs Code.:
DSSTox Substance ID:DTXSID60215491
ChEMBL ID:CHEMBL542898
Mol file:65189-49-3.mol

Synonyms:65189-49-3;Benzamide, N-(3-((4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)-, monohydrochloride;N-(3-((4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)benzamide monohydrochloride;CHEMBL542898;DTXSID60215491;LS-25513

Suppliers and Price of Benzamide, N-(3-((4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)-, monohydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Benzamide, N-(3-((4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)-, monohydrochloride

Chemical Property:

PSA：106.82000
LogP:3.79240
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:431.1724174
Heavy Atom Count:30
Complexity:517

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(CCCNC(=O)C1=CC=CC=C1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC.Cl

Technology Process of Benzamide, N-(3-((4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)-, monohydrochloride

There total 3 articles about Benzamide, N-(3-((4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 98902-17-1
N-(3-(methylamino)propyl)benzamide

: 23680-84-4
2-chloro-6,7-dimethoxyquinazolin-4-amine

: 65189-49-3
N-{3-[(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-methyl-amino]-propyl}-benzamide; hydrochloride

Guidance literature:: In i-Amyl alcohol; for 12h; Heating;
DOI:10.1021/jm00151a003

Reference yield:

: 23873-66-7
N-methyl-N-cyanoethyl benzamide

: 65189-49-3
N-{3-[(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-methyl-amino]-propyl}-benzamide; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: H₂, 10percent ethanolic NH₃ / Rh/C / 80 °C / 43440.4 Torr

2: 67 percent / 3-methyl-butan-1-ol / 12 h / Heating

With ammonia; hydrogen; Rh on carbon; In i-Amyl alcohol;
DOI:10.1021/jm00151a003

Reference yield:

: 98-88-4
benzoyl chloride

: 65189-49-3
N-{3-[(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-methyl-amino]-propyl}-benzamide; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / 1 h / Ambient temperature

2: H₂, 10percent ethanolic NH₃ / Rh/C / 80 °C / 43440.4 Torr

3: 67 percent / 3-methyl-butan-1-ol / 12 h / Heating

With ammonia; hydrogen; triethylamine; Rh on carbon; In tetrahydrofuran; i-Amyl alcohol;
DOI:10.1021/jm00151a003