ethyl 2-(2-phenyl-1H-indol-1-yl)acetate

Base Information

• Chemical Name: ethyl 2-(2-phenyl-1H-indol-1-yl)acetate
• CAS No.: 65746-57-8
• Molecular Formula: C18H17NO2
• Molecular Weight: 279.338
• Hs Code.: 29339900
• Mol file: 65746-57-8.mol

Synonyms:ethyl 2-(2-phenyl-1H-indol-1-yl)acetate;1H-Indole-1-acetic acid,2-phenyl-,ethyl ester;

Chemical Property of ethyl 2-(2-phenyl-1H-indol-1-yl)acetate

Chemical Property:

• Boiling Point: 453.8±28.0 °C(Predicted)
• PSA: 31.23000
• Density: 1.11±0.1 g/cm3(Predicted)
• LogP: 3.87140

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-(2-phenyl-1H-indol-1-yl)acetate 97% ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-(2-phenyl-1H-indol-1-yl)acetate

There total 3 articles about ethyl 2-(2-phenyl-1H-indol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-phenyl-indole (948-65-2) + ethyl bromoacetate (105-36-2) → ethyl 2-(2-phenyl-1H-indol-1-yl)acetate (65746-57-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1080/00397910500212965

Reference yield:

2-(2-phenyl-indol-1-yl)-propionic acid ethyl ester (908372-60-1) → ethyl 2-(2-phenyl-1H-indol-1-yl)acetate (65746-57-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 38 percent / sodium hydroxide / ethanol / 0.5 h / 80 °C

2: diethyl ether / 2 h / 20 °C

3: sodium hydride / dimethylformamide / 0 - 20 °C

With sodium hydroxide; sodium hydride; In diethyl ether; ethanol; N,N-dimethyl-formamide;

DOI:10.1080/00397910500212965

Reference yield:

2-(2-phenyl-1H-indol-1-yl)propionic acid (871584-18-8) → ethyl 2-(2-phenyl-1H-indol-1-yl)acetate (65746-57-8)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 2 h / 20 °C

2: sodium hydride / dimethylformamide / 0 - 20 °C

With sodium hydride; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1080/00397910500212965

upstream raw materials:

2-phenyl-indole

ethyl bromoacetate

2-(2-phenyl-indol-1-yl)-propionic acid ethyl ester

2-(2-phenyl-1H-indol-1-yl)propionic acid

Downstream raw materials:

2-(2-phenyl-1H-indol-1-yl)ethan-1-ol

2-(2-phenyl-1H-indol-1-yl)acetic acid

2-(2-phenyl-1H-indol-1-yl)acetaldehyde

1-(2-phenyl-1H-indol-1-yl)propan-2-one

Refernces

• 1、 Ding, Huasheng,Zhang, Chao,Wu, Xihan,Yang, Chunhao,Zhang, Xiongwen,Ding, Jian,Xie, Yuyuan. "Novel indole α-methylene-γ-lactones as potent inhibitors for AKT-mTOR signaling pathway kinases". . p. 4799 - 4802. Retrieved 2007/10/03.