Ethyl 2-(2-phenyl-1H-indol-1-yl)acetate

Base Information

• Chemical Name: Ethyl 2-(2-phenyl-1H-indol-1-yl)acetate
• CAS No.: 65746-57-8
• Molecular Formula: C18H17NO2
• Molecular Weight: 279.338
• Hs Code.: 29339900
• DSSTox Substance ID: DTXSID10470750
• Nikkaji Number: J2.244.274K
• Wikidata: Q82298912

Synonyms:Ethyl 2-(2-phenyl-1H-indol-1-yl)acetate;65746-57-8;Ethyl 2-(2-phenylindol-1-yl)acetate;DTXSID10470750;MFCD11046346;AKOS009165426;BS-50559;Ethyl2-(2-phenyl-1H-indol-1-yl)acetate;CS-0187808;FT-0734525;E76486

Chemical Property of Ethyl 2-(2-phenyl-1H-indol-1-yl)acetate

Chemical Property:

• Boiling Point: 453.8±28.0 °C(Predicted)
• PSA: 31.23000
• Density: 1.11±0.1 g/cm3(Predicted)
• LogP: 3.87140
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 279.125928785
• Heavy Atom Count: 21
• Complexity: 351

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-(2-phenyl-1H-indol-1-yl)acetate 97% ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CN1C2=CC=CC=C2C=C1C3=CC=CC=C3

Technology Process of Ethyl 2-(2-phenyl-1H-indol-1-yl)acetate

There total 3 articles about Ethyl 2-(2-phenyl-1H-indol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-phenyl-indole (948-65-2) + ethyl bromoacetate (105-36-2) → ethyl 2-(2-phenyl-1H-indol-1-yl)acetate (65746-57-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1080/00397910500212965

Reference yield:

2-(2-phenyl-indol-1-yl)-propionic acid ethyl ester (908372-60-1) → ethyl 2-(2-phenyl-1H-indol-1-yl)acetate (65746-57-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 38 percent / sodium hydroxide / ethanol / 0.5 h / 80 °C

2: diethyl ether / 2 h / 20 °C

3: sodium hydride / dimethylformamide / 0 - 20 °C

With sodium hydroxide; sodium hydride; In diethyl ether; ethanol; N,N-dimethyl-formamide;

DOI:10.1080/00397910500212965

Reference yield:

2-(2-phenyl-1H-indol-1-yl)propionic acid (871584-18-8) → ethyl 2-(2-phenyl-1H-indol-1-yl)acetate (65746-57-8)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 2 h / 20 °C

2: sodium hydride / dimethylformamide / 0 - 20 °C

With sodium hydride; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1080/00397910500212965

upstream raw materials:

2-phenyl-indole

ethyl bromoacetate

2-(2-phenyl-indol-1-yl)-propionic acid ethyl ester

2-(2-phenyl-1H-indol-1-yl)propionic acid

Downstream raw materials:

2-(2-phenyl-1H-indol-1-yl)propanol

2-(2-phenyl-indol-1-yl)-propionic acid ethyl ester

2-phenyl-indole

1-(2-phenyl-1H-indol-1-yl)propan-2-one

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