1-(3-Fluorophenyl)-2-(4-pyridyl)ethanone

Base Information

Chemical Name:1-(3-Fluorophenyl)-2-(4-pyridyl)ethanone
CAS No.:6576-04-1
Molecular Formula:C13H10FNO
Molecular Weight:215.227
Hs Code.:
DSSTox Substance ID:DTXSID70460177
Wikidata:Q82284134

Synonyms:1-(3-Fluorophenyl)-2-pyridin-4-ylethanone;6576-04-1;1-(3-FLUOROPHENYL)-2-(4-PYRIDYL)ETHANONE;SCHEMBL1156959;DTXSID70460177;VUVBFCUAAOZARP-UHFFFAOYSA-N;AKOS011843552;1-(3-fluorophenyl)-2-(pyridin-4-yl)ethanone;A1-27047

Suppliers and Price of 1-(3-Fluorophenyl)-2-(4-pyridyl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1-(3-Fluorophenyl)-2-(4-pyridyl)ethanone

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:215.074642105
Heavy Atom Count:16
Complexity:238

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC(=C1)F)C(=O)CC2=CC=NC=C2

Technology Process of 1-(3-Fluorophenyl)-2-(4-pyridyl)ethanone

There total 4 articles about 1-(3-Fluorophenyl)-2-(4-pyridyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 108-89-4
picoline

: 451-02-5
ethyl 3-fluorobenzoate

: 6576-04-1
1-(3-fluorophenyl)-2-(4-pyridyl)ethanone

Guidance literature:: picoline; ethyl 3-fluorobenzoate; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at 0 - 20 ℃;

With ammonium chloride; In water; ethyl acetate;

Reference yield: 80.0%

: 325770-39-6
1-(3-fluorobenzoyl)-2-methylaziridine

: 108-89-4
picoline

: 6576-04-1
1-(3-fluorophenyl)-2-(4-pyridyl)ethanone

Guidance literature:: picoline; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -10 ℃; for 0.333333h;

1-(3-fluorobenzoyl)-2-methylaziridine; In tetrahydrofuran; hexane; at -78 ℃; for 1h;
DOI:10.1248/cpb.53.410

Reference yield:

: 1711-07-5
3-fluorobenzoyl chloride

: 6576-04-1
1-(3-fluorophenyl)-2-(4-pyridyl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 77 percent / aq. NaOH / diethyl ether / 0 °C

2.1: LDA / tetrahydrofuran; hexane / 0.33 h / -10 °C

2.2: 80 percent / tetrahydrofuran; hexane / 1 h / -78 °C

With sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1248/cpb.53.410