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4-Methylpyridine

Base Information Edit
  • Chemical Name:4-Methylpyridine
  • CAS No.:108-89-4
  • Deprecated CAS:82005-09-2,92075-35-9
  • Molecular Formula:C6H7N
  • Molecular Weight:93.1283
  • Hs Code.:29333955
  • European Community (EC) Number:203-626-4
  • ICSC Number:0803
  • NSC Number:18252
  • UN Number:2313
  • UNII:TJD6V9SSO7
  • DSSTox Substance ID:DTXSID4021892
  • Nikkaji Number:J5.084I
  • Wikipedia:4-Methylpyridine
  • Wikidata:Q2189778
  • Metabolomics Workbench ID:54619
  • ChEMBL ID:CHEMBL15544
  • Mol file:108-89-4.mol
4-Methylpyridine

Synonyms:4-methylpyridine;4-methylpyridinium

Suppliers and Price of 4-Methylpyridine
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • 4-Methylpyridine
  • 50g
  • $ 195.00
  • TCI Chemical
  • 4-Methylpyridine >98.0%(GC)(T)
  • 25mL
  • $ 15.00
  • TCI Chemical
  • 4-Methylpyridine >98.0%(GC)(T)
  • 500mL
  • $ 33.00
  • SynQuest Laboratories
  • 4-Methylpyridine
  • 25 g
  • $ 27.00
  • SynQuest Laboratories
  • 4-Methylpyridine
  • 100 g
  • $ 45.00
  • Sigma-Aldrich
  • 4-Picoline analytical standard
  • 5ml
  • $ 249.00
  • Sigma-Aldrich
  • 4-Picoline analytical standard
  • 1ml
  • $ 62.70
  • Sigma-Aldrich
  • 4-Methylpyridine for synthesis. CAS 108-89-4, molar mass 93.13 g/mol., for synthesis
  • 8070490010
  • $ 19.00
  • Sigma-Aldrich
  • 4-Methylpyridine for synthesis
  • 10 mL
  • $ 18.22
  • Sigma-Aldrich
  • 4-Methylpyridine for synthesis. CAS 108-89-4, molar mass 93.13 g/mol., for synthesis
  • 8070490500
  • $ 43.70
Total 32 raw suppliers
Chemical Property of 4-Methylpyridine Edit
Chemical Property:
  • Appearance/Colour:colourless liquid 
  • Vapor Pressure:4 mm Hg ( 20 °C) 
  • Melting Point:2.4 °C(lit.) 
  • Refractive Index:n20/D 1.504(lit.)  
  • Boiling Point:144.2 °C at 760 mmHg 
  • PKA:6.02(at 20℃) 
  • Flash Point:40 °C 
  • PSA:12.89000 
  • Density:0.95 g/cm3 
  • LogP:1.39000 
  • Storage Temp.:Flammables area 
  • Sensitive.:Air Sensitive & Hygroscopic 
  • Solubility.:alcohol: soluble(lit.) 
  • Water Solubility.:soluble 
  • XLogP3:1.2
  • Hydrogen Bond Donor Count:0
  • Hydrogen Bond Acceptor Count:1
  • Rotatable Bond Count:0
  • Exact Mass:93.057849228
  • Heavy Atom Count:7
  • Complexity:46.1
  • Transport DOT Label:Flammable Liquid
Purity/Quality:

99.0%Min *data from raw suppliers

4-Methylpyridine *data from reagent suppliers

Safty Information:
  • Pictogram(s): Toxic
  • Hazard Codes:
  • Statements: 10-20/22-24-36/37/38 
  • Safety Statements: 26-36-45 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Chemical Classes:Nitrogen Compounds -> Pyridines
  • Canonical SMILES:CC1=CC=NC=C1
  • Inhalation Risk:A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.
  • Effects of Short Term Exposure:The substance is corrosive to the eyes and skin. The vapour is irritating to the respiratory tract. Exposure at high levels could cause unconsciousness.
  • Effects of Long Term Exposure:The substance defats the skin, which may cause dryness or cracking.
  • Uses 4-Methylpyridine is used to manufacture isonicotinic acid and derivatives, in waterproofing agents for fabric, and as a solvent for resins, pharmaceuticals, dyestuffs, rubber accelerators, and pesticides. It is also used as a catalyst and curing agent. 4-Methylpyridine was used in the preparation of a 1,2-dihydropyridide derivative.
Technology Process of 4-Methylpyridine

There total 272 articles about 4-Methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With hydrogenchloride; In water; for 0.5h; Product distribution; Ambient temperature; variation of pH, temp. and time;
DOI:10.1016/S0040-4039(01)93895-X
Guidance literature:
With tetraethylammonium perchlorate; In acetonitrile; at 20 ℃; Rate constant; electrolyse, -0.89 V;
Guidance literature:
With sodium cyanide; In water; N,N-dimethyl-formamide; a) reflux, 3 h, b) steam bath, 2 h;
DOI:10.1021/jm00050a006
Refernces Edit

Syntheses, characterizations and theoretical calculations of rhodium(III) 1,2-naphthoquinone-1-oxime complexes

10.1016/j.ica.2009.12.033

The research aims to synthesize and characterize a series of rhodium(III) complexes containing the 1,2-naphthoquinone-1-oxime (1-nqo) ligand and different pyridine-type co-ligands (4-methylpyridine, 4-phenylpyridine, and 4-acetylpyridine). The purpose is to investigate their electronic transition behaviors and electrochemical properties. The study employs various characterization techniques, including single crystal X-ray crystallography, mass spectrometry, 1H–1H COSY NMR, FT-IR, UV–Vis absorption spectroscopy, and cyclic voltammetry, as well as theoretical calculations using DFT and TD-DFT methods. The key findings include the identification of metal to 1-nqo ligand charge transfer (MLCT) and chloride to 1-nqo ligand charge transfer (LLCT) transitions in the UV–Vis spectra, and the observation of irreversible, metal-localized two-electron reductions in the cyclic voltammograms. The research concludes that the electronic properties of these complexes are influenced by the nature of the pyridine-type co-ligands, with changes in their electron-donating ability affecting the energy levels of the triplet orbitals and the reductive potentials of the complexes.

Iridium-Catalyzed C-Alkylation of Methyl Group on N-Heteroaromatic Compounds using Alcohols

10.1021/acs.orglett.0c02635

The study presents the development of a catalytic system for the C-alkylation of N-heterocyclic compounds, such as pyridine, pyrimidine, pyrazine, quinoline, quinoxaline, and isoquinoline, using alcohols. The process is based on a hydrogen-borrowing approach and utilizes [Cp*IrCl2]2 as the catalyst precursor, combined with potassium t-butoxide and 18-crown-6-ether. This method is environmentally friendly as it only produces water as a byproduct. The researchers optimized the reaction conditions and demonstrated the system's versatility by applying it to various substrates, achieving good to excellent yields. The study also proposed a possible reaction mechanism involving three steps: hydrogen transfer from alcohol to iridium catalyst, cross-aldol-type condensation, and transfer hydrogenation. The developed catalytic system is expected to contribute to the synthesis of pharmaceuticals and functional materials.

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