1-(4-Pyridinyl)-2-(dimethylamino)ethenyl methyl ketone

Base Information

Chemical Name:1-(4-Pyridinyl)-2-(dimethylamino)ethenyl methyl ketone
CAS No.:78504-61-7
Molecular Formula:C11H14 N2 O
Molecular Weight:190.245
Hs Code.:2933399090
DSSTox Substance ID:DTXSID101243082
Mol file:78504-61-7.mol

Synonyms:4-(Dimethylamino)-3-(4-pyridinyl)-3-buten-2-one;SCHEMBL10969443;QEJJLSDONYSIPV-UHFFFAOYSA-N;DTXSID101243082;1-(4-Pyridinyl)-2-(dimethylamino)ethenyl methyl ketone

Suppliers and Price of 1-(4-Pyridinyl)-2-(dimethylamino)ethenyl methyl ketone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 1-(4-Pyridinyl)-2-(dimethylamino)ethenyl methyl ketone

Chemical Property:

Vapor Pressure:8.58E-05mmHg at 25°C
Boiling Point:340.5°C at 760 mmHg
Flash Point:159.7°C
PSA：33.20000
Density:1.051g/cm³
LogP:1.57310
XLogP3:0.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:190.110613074
Heavy Atom Count:14
Complexity:227

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C(=CN(C)C)C1=CC=NC=C1

Technology Process of 1-(4-Pyridinyl)-2-(dimethylamino)ethenyl methyl ketone

There total 5 articles about 1-(4-Pyridinyl)-2-(dimethylamino)ethenyl methyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.3%

: 1-acetyl-4-(acetylmethylidene)-1,4-dihydropyridine

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 78504-61-7
4-(dimethylamino)-3-(pyridin-4-yl)but-3-en-2-one

Guidance literature:: In 1,4-dioxane; Solvent; Reflux;

Reference yield: 67.0%

: 6304-16-1
pyridin-4-yl-propan-2-one

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 78504-61-7
4-(dimethylamino)-3-(pyridin-4-yl)but-3-en-2-one

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1002/jlcr.2580220213

Reference yield:

: 108-89-4
picoline

: 78504-61-7
1-(4-pyridinyl)-2-(dimethylamino)ethenyl methyl ketone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, hexane, HMPA, 0 deg C, 30 min, 2.) THF, hexane, HMPA, RT, 90 min

2: dimethylformamide / 4.5 h / 50 - 65 °C

With lithium diisopropyl amide; In N,N-dimethyl-formamide;
DOI:10.1021/jm00155a009