5-Methyl-2-pyridinesulfonamide

Base Information

• Chemical Name: 5-Methyl-2-pyridinesulfonamide
• CAS No.: 65938-77-4
• Molecular Formula: C6H8N2O2S
• Molecular Weight: 172.208
• Hs Code.: 2935009090
• European Community (EC) Number: 628-444-6
• DSSTox Substance ID: DTXSID70394266
• Nikkaji Number: J2.112.080D
• Wikidata: Q72496653
• Mol file: 65938-77-4.mol

Synonyms:5-Methyl-2-pyridinesulfonamide;65938-77-4;5-methylpyridine-2-sulfonamide;2-Pyridinesulfonamide, 5-methyl-;MFCD00661363;5-methyl-pyridine-2-sulfonamide;SCHEMBL51542;5-methyl-2-pyridinesulphonamide;DTXSID70394266;HXURYNQXMBRJLU-UHFFFAOYSA-N;AKOS010998596;CS-W017596;FS-3145;SB52434;5-Methyl-2-pyridinesulfonamide, >=97%;SY014673;AM20061861;FT-0686164;EN300-208228;A867567;J-517770;J-650264

Chemical Property of 5-Methyl-2-pyridinesulfonamide

Chemical Property:

• Vapor Pressure: 2.09E-05mmHg at 25°C
• Melting Point: 127-132?°C
• Refractive Index: 1.564
• Boiling Point: 361.3oC at 760 mmHg
• PKA: 9.33±0.60(Predicted)
• Flash Point: 172.3oC
• PSA: 81.43000
• Density: 1.346g/cm3
• LogP: 1.81850
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 172.03064868
• Heavy Atom Count: 11
• Complexity: 219

Purity/Quality:

97% ^*data from raw suppliers

5-Methyl-2-pyridinesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 389057
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=C(C=C1)S(=O)(=O)N
• Uses: 5-METHYLPYRIDINE-2-SULFONAMIDE is a arylsulfonamide used as an intermeditae in the preparation of the endothelin receptor antagonist, Clazosentan. 5-Methyl-2-pyridinesulfonamide is also used as a reagent in the preparation of aziridines via copper or iron-catalyzed aziridination. 5-Methyl-2-pyridinesulfonamide was used to develop a copper-catalyzed aziridination protocol.

Technology Process of 5-Methyl-2-pyridinesulfonamide

There total 2 articles about 5-Methyl-2-pyridinesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ammonium hydroxide (1336-21-6) + 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran (96042-30-7) + 2-mercapto-5-methylpyridine (18368-58-6) → 5-methyl-2-pyridinesulfonamide (65938-77-4)

Guidance literature:

With hydrogenchloride; sodium hypochlorite; In tetrahydrofuran;

Reference yield:

2-Bromo-5-methylpyridine (3510-66-5) + (hydroxylamino)sulfonic acid (13598-45-3) + N,N,N,N,-tetramethylethylenediamine (110-18-9) + sulfur dioxide (7446-09-5,12143-17-8,89125-89-3) → 5-methyl-2-pyridinesulfonamide (65938-77-4)

Guidance literature:

With sodium hydroxide; sec.-butyllithium; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; cyclohexane; water;

Reference yield: 94.0%

racemic methyl phenyl sulfoxide (1193-82-4) + 5-methyl-2-pyridinesulfonamide (65938-77-4) → N-(4-methyl-2-pyridinylsulfonyl)-S-methyl-S-phenylsulfoximine

Guidance literature:

With [bis(acetoxy)iodo]benzene; silver nitrate; 4,4',4-tri-tert-butyl-2,2':6',2-terpyridine; In acetonitrile; at 20 ℃; for 168h;

DOI:10.1021/ol0519442

upstream raw materials:

ammonium hydroxide

4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

2-mercapto-5-methylpyridine

2-Bromo-5-methylpyridine

Downstream raw materials:

5-methyl-2-[(2-phenylaziridin-1-yl)sulfonyl]pyridine

(RS)-S-methyl-S-(4-nitrophenyl)-N-[(5-methyl-2-pyridyl)sulphonyl]sulphimide

N-(2-phenylpropyl)(5-methyl-2-pyridine)sulfonamide