4H-1,3-Benzodioxin-4-one, 5-[(2R)-2-hydroxy-4-pentenyl]-2,2-dimethyl-

Base Information

Chemical Name:4H-1,3-Benzodioxin-4-one, 5-[(2R)-2-hydroxy-4-pentenyl]-2,2-dimethyl-
CAS No.:659738-79-1
Molecular Formula:C15H18O4
Molecular Weight:262.306
Hs Code.:

Synonyms:

Suppliers and Price of 4H-1,3-Benzodioxin-4-one, 5-[(2R)-2-hydroxy-4-pentenyl]-2,2-dimethyl-

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Chemical Property of 4H-1,3-Benzodioxin-4-one, 5-[(2R)-2-hydroxy-4-pentenyl]-2,2-dimethyl-

Chemical Property:

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Technology Process of 4H-1,3-Benzodioxin-4-one, 5-[(2R)-2-hydroxy-4-pentenyl]-2,2-dimethyl-

There total 1 articles about 4H-1,3-Benzodioxin-4-one, 5-[(2R)-2-hydroxy-4-pentenyl]-2,2-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 154714-19-9
5-hydroxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one

: 659738-79-1
(R)-5-(2-hydroxypent-4-enyl)-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 1 h / 0 °C

2: lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 48 h / Reflux

3: 4-methylmorpholine N-oxide; osmium(VIII) oxide / acetone; water / 4 h / 20 °C

4: sodium periodate; sodium hydrogencarbonate / tetrahydrofuran; water / 0.5 h / 0 - 20 °C

5: dichloromethane; pentane / 2 h / -100 °C

With pyridine; sodium periodate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; lithium chloride; In tetrahydrofuran; dichloromethane; water; acetone; pentane; 2: |Stille Cross Coupling;
DOI:10.1016/j.tetlet.2014.03.067

Reference yield:

: 659738-79-1
(R)-5-(2-hydroxypent-4-enyl)-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one

: 1603885-68-2
(R)-3-((S,E)-4-(benzyloxy)pent-2-enyl)-8-methoxyisochroman-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / -20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 0 - 20 °C

3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 3 h / 60 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; sodium hydride; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3: |Grubbs Olefin Metathesis;
DOI:10.1016/j.tetlet.2014.03.067

Reference yield:

: 659738-79-1
(R)-5-(2-hydroxypent-4-enyl)-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one

: (R)-3-((S,E)-4-(benzyloxy)pent-2-enyl)-8-hydroxyisochroman-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / -20 °C

2: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 3 h / 60 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: |Grubbs Olefin Metathesis;
DOI:10.1016/j.tetlet.2014.03.067