Benzamide, N-[(1E,4S)-5-[(2S,4R,6S)-4-(acetyloxy)-6-[(2,2-dimethyl-4-oxo-4H-1,3- benzodioxin-5-yl)methyl]tetrahydro-2H-pyran-2-yl]-4-hydroxy-1-pentenyl] -

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Chemical Name:Benzamide, N-[(1E,4S)-5-[(2S,4R,6S)-4-(acetyloxy)-6-[(2,2-dimethyl-4-oxo-4H-1,3- benzodioxin-5-yl)methyl]tetrahydro-2H-pyran-2-yl]-4-hydroxy-1-pentenyl] -
CAS No.:659739-05-6
Molecular Formula:C30H35NO8
Molecular Weight:537.61
Hs Code.:

Benzamide,
N-[(1E,4S)-5-[(2S,4R,6S)-4-(acetyloxy)-6-[(2,2-dimethyl-4-oxo-4H-1,3-
benzodioxin-5-yl)methyl]tetrahydro-2H-pyran-2-yl]-4-hydroxy-1-pentenyl]
-

Synonyms:

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Chemical Property of Benzamide, N-[(1E,4S)-5-[(2S,4R,6S)-4-(acetyloxy)-6-[(2,2-dimethyl-4-oxo-4H-1,3- benzodioxin-5-yl)methyl]tetrahydro-2H-pyran-2-yl]-4-hydroxy-1-pentenyl] -

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Technology Process of Benzamide, N-[(1E,4S)-5-[(2S,4R,6S)-4-(acetyloxy)-6-[(2,2-dimethyl-4-oxo-4H-1,3- benzodioxin-5-yl)methyl]tetrahydro-2H-pyran-2-yl]-4-hydroxy-1-pentenyl] -

There total 2 articles about Benzamide, N-[(1E,4S)-5-[(2S,4R,6S)-4-(acetyloxy)-6-[(2,2-dimethyl-4-oxo-4H-1,3- benzodioxin-5-yl)methyl]tetrahydro-2H-pyran-2-yl]-4-hydroxy-1-pentenyl] - which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 659739-04-5
Acetic acid (2R,4R,6S)-2-[(E)-(S)-5-benzoylamino-2-(tert-butyl-dimethyl-silanyloxy)-pent-4-enyl]-6-(2,2-dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-ylmethyl)-tetrahydro-pyran-4-yl ester

: 659739-05-6
Acetic acid (2S,4R,6S)-2-((E)-(S)-5-benzoylamino-2-hydroxy-pent-4-enyl)-6-(2,2-dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-ylmethyl)-tetrahydro-pyran-4-yl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃;
DOI:10.1002/chem.200305230

Reference yield:

: 55-21-0,27208-38-4
benzamide

: 659739-05-6
Acetic acid (2S,4R,6S)-2-((E)-(S)-5-benzoylamino-2-hydroxy-pent-4-enyl)-6-(2,2-dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-ylmethyl)-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 37 percent / CuTC; Rb₂CO₃ / N,N-dimethyl-acetamide / 90 °C

2: 73 percent / TBAF / tetrahydrofuran / 25 °C

With rubidium carbonate; copper(I) thiophene-2-carboxylate; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl acetamide;
DOI:10.1002/chem.200305230

Reference yield: 31.0%

: 659739-05-6
Acetic acid (2S,4R,6S)-2-((E)-(S)-5-benzoylamino-2-hydroxy-pent-4-enyl)-6-(2,2-dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-ylmethyl)-tetrahydro-pyran-4-yl ester

: N-[(E)-3-((1S,11S,13R,15R)-7,15-Dihydroxy-9-oxo-10,17-dioxa-tricyclo[11.3.1.0^3,8]heptadeca-3⁽⁸⁾,4,6-trien-11-yl)-propenyl]-benzamide

Guidance literature:: Acetic acid (2S,4R,6S)-2-((E)-(S)-5-benzoylamino-2-hydroxy-pent-4-enyl)-6-(2,2-dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-ylmethyl)-tetrahydro-pyran-4-yl ester; With sodium hydride; In tetrahydrofuran; at 25 ℃;

With water; In tetrahydrofuran; at 25 ℃; Further stages.;
DOI:10.1002/chem.200305230