Chemical Property of Benzamide
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Chemical Property:
- Appearance/Colour:off-white crystals or powder
- Vapor Pressure:0.0024mmHg at 25°C
- Melting Point:125-128 °C(lit.)
- Refractive Index:1.564
- Boiling Point:288 °C at 760 mmHg
- PKA:16.00±0.50(Predicted)
- Flash Point:127.978 °C
- PSA：43.09000
- Density:1.12 g/cm3
- LogP:1.48580
- Storage Temp.:Store below +30°C.
- Solubility.:ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to light yellow
- Water Solubility.:1.35 g/100 mL (20℃)
- XLogP3:0.6
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:1
- Rotatable Bond Count:1
- Exact Mass:121.052763847
- Heavy Atom Count:9
- Complexity:106
- Purity/Quality:
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99.9% *data from raw suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:
Xn:Harmful;
- Statements:
R22:;
- Safety Statements:
22-24/25-36/37
- MSDS Files:
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Total 1 MSDS from other Authors
Useful:
- Chemical Classes:Nitrogen Compounds -> Other Aromatics (Nitrogen)
- Canonical SMILES:C1=CC=C(C=C1)C(=O)N
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Description
Benzamide appears as off-white crystals or powder. It is combustible and incompatible with strong oxidising agents and strong bases. On combustion and thermal decomposition, it emits nitrogen oxides, carbon monoxide, and carbon dioxide.
Benzamide is a carbonic acid amide of benzoic acid. Benzamide exhibits an angle of about 15o with the plane of the amide group; this shows that benzamide molecule is not flat. The rotation of the amide group relative to the aromatic ring may result from the repulsion interaction between the hydrogen atoms of the amide group and those of the aromatic ring.
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Uses
Organic synthesis.Benzamide on radioiodination by different labeling procedures results in large-scale production of radioiodinated benzamides having potential therapeutic application for patients with metastatic malignant melanoma. Benzamide is utilized to study the mechanism of photocatalytic decomposition of aqueous solution of acetic acid, acetamide and acetonitrile in the presence of semiconductors. It is used as a nictoinamide-mimic PARP inhibitor and neuroprotectant. Further, it is used to develop a robust screening method to study biotransformations using (+)-gamma-lactamase enzyme. It is also employed in the determination of glycine. In addition to this, it is used as an intermediate in organic synthesis as well as in the production of pharmaceuticals and dyes.
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Clinical Use
Benzamide on radioiodination by different labeling procedures results in large-scale production of radioiodinated benzamides having potential therapeutic application for patients with metastatic malignant melanoma.
