Benzenemethanol, 2,4-bis(methoxymethoxy)-

Base Information

Chemical Name:Benzenemethanol, 2,4-bis(methoxymethoxy)-
CAS No.:659746-74-4
Molecular Formula:C11H16O5
Molecular Weight:228.245
Hs Code.:
DSSTox Substance ID:DTXSID50457282
Nikkaji Number:J2.154.395K
Wikidata:Q82280069

Synonyms:659746-74-4;Benzenemethanol, 2,4-bis(methoxymethoxy)-;DTXSID50457282;2,4-Bis(methoxymethoxy)benzyl alcohol

Suppliers and Price of Benzenemethanol, 2,4-bis(methoxymethoxy)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Benzenemethanol, 2,4-bis(methoxymethoxy)-

Chemical Property:

XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:228.09977361
Heavy Atom Count:16
Complexity:176

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COCOC1=CC(=C(C=C1)CO)OCOC

Technology Process of Benzenemethanol, 2,4-bis(methoxymethoxy)-

There total 1 articles about Benzenemethanol, 2,4-bis(methoxymethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 13709-06-3
2,4-bis(methoxymethoxy)benzaldehyde

: 659746-74-4
2,4-bis(methoxymethyloxy)benzyl alkohol

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 20 ℃; for 2h;
DOI:10.3987/com-03-s19 DOI:10.1248/cpb.53.393

Reference yield: 95.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 659746-74-4
2,4-bis(methoxymethyloxy)benzyl alkohol

: 659746-75-5
1,3-bis(methoxymethyloxy)-4-(tert-butyldimethylsilyloxymethyl)benzene

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1248/cpb.53.393

Reference yield:

: 659746-74-4
2,4-bis(methoxymethyloxy)benzyl alkohol

: 659746-84-6
methyl [6-formyl-2-(methoxyiminomethyl)-3-(prop-1-en-1-yl)phenyloxy]acetate

Guidance literature:: Multi-step reaction with 10 steps

1.1: 95 percent / imidazole / dimethylformamide / 12 h / 20 °C

2.1: n-BuLi / hexane; tetrahydrofuran / 0.67 h / cooling

2.2: 75 percent / hexane; tetrahydrofuran / 0.33 h / cooling

3.1: 89 percent / AcONa / ethanol / 12 h / 80 °C

4.1: 91 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

5.1: 89 percent / MnO₂ / CH₂Cl₂ / 24 h / 20 °C

6.1: 92 percent / aq. HCl / methanol / 3 h / 0 °C

7.1: NaH / dimethylformamide / 0.5 h / cooling

7.2: 93 percent / dimethylformamide / 12 h / 20 °C

8.1: 80 percent / AcOH / 12 h / 90 °C

9.1: 85 percent / pyridine / CH₂Cl₂ / 4 h / cooling

10.1: 83 percent / Et₄NCl; PdCl₂(PPh₃)2 / dimethylformamide / 4 h / 80 °C

With pyridine; 1H-imidazole; hydrogenchloride; manganese(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; tetraethylammonium chloride; tetrabutyl ammonium fluoride; sodium acetate; sodium hydride; acetic acid; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; 10.1: Stille coupling;
DOI:10.1248/cpb.53.393