N-succinimidyl 4-iodobenzoate

Base Information

• Chemical Name: N-succinimidyl 4-iodobenzoate
• CAS No.: 39028-25-6
• Molecular Formula: C11H8INO4
• Molecular Weight: 345.093
• Hs Code.: 2925190090
• Mol file: 39028-25-6.mol

Synonyms:2,5-Pyrrolidinedione,1-((4-iodobenzoyl)oxy);p-Iodbenzoesaeure-N-hydroxysuccinimidester;1-[(4-iodobenzoyl)oxy]pyrrolidine-2,5-dione;4-iodobenzoic acid succinimide ester;N-succinimidyl-4-iodobenzoate;N-hydroxysuccinimidyl-4-iodobenzoate;NS-p-IB;succinimidyl 4-iodobenzoate;4-iodobenzoic acid N-hydroxysuccinimidyl ester;

Chemical Property of N-succinimidyl 4-iodobenzoate

Chemical Property:

• Vapor Pressure: 3.66E-07mmHg at 25°C
• Boiling Point: 417°Cat760mmHg
• Flash Point: 206°C
• PSA: 63.68000
• Density: 1.94g/cm³
• LogP: 1.44990
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,5-Dioxopyrrolidin-1-yl4-iodobenzoate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-succinimidyl 4-iodobenzoate

There total 7 articles about N-succinimidyl 4-iodobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 4-iodobenzoic acid (619-58-9) → 2,5-dioxopyrrolidin-1-yl 4-iodobenzoate (39028-25-6)

Guidance literature:

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; for 2h; Heating;

DOI:10.1039/b504248h

Reference yield: 98.4%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 3-Iodobenzoic acid (618-51-9) → 2,5-dioxopyrrolidin-1-yl 4-iodobenzoate (39028-25-6)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 22h;

DOI:10.1002/jlcr.3925

Reference yield: 90.0%

N-succinimidyl-4-[3,3-(1,4-butanediyl)-triazene]benzoate (336611-57-5) → 2,5-dioxopyrrolidin-1-yl 4-iodobenzoate (39028-25-6)

Guidance literature:

With chloro-trimethyl-silane; sodium iodide; In acetonitrile; at 75 ℃; for 0.75h;

DOI:10.1002/jlcr.451

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

4-iodobenzoic acid

N-succinimidyl-4-[3,3-(1,4-butanediyl)-triazene]benzoate

4-amino-benzoic acid

Downstream raw materials:

(C₅H₅)W(CO)3C₆H₄C(O)ONC₄H₄O₂

4-(tributylstannyl)benzoic acid N-hydroxyl succinimidyl ester

N-succinimidyl 4-[18F]fluorobenzoate

Refernces

• 1、 Kim, Kyul,Kwon, Hongmok,Barinka, Cyril,Motlova, Lucia,Nam, Sangjin,Choi, Doyoung,Ha, Hyunsoo,Nam, Hwanhee,Son, Sang-Hyun,Minn, Il,Pomper, Martin G.,Yang, Xing,Kutil, Zsofia,Byun, Youngjoo. "Novel β- And γ-Amino Acid-Derived Inhibitors of Prostate-Specific Membrane Antigen". supporting information. p. 3261 - 3273. Retrieved 2020/04/10.
• 2、 -. "PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) INHIBITORS AS diAGNOSTIC AND RAdiONUCLIDE THERAPEUTIC AGENTS". Paragraph 0101-0102. . Retrieved 2020/11/03.