N-(6-methoxy-6-oxohexanoyl)-L-valyl-L-valyl-(4R)-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-4-[(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)oxy]-L-prolinamide

Base Information

Chemical Name:N-(6-methoxy-6-oxohexanoyl)-L-valyl-L-valyl-(4R)-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-4-[(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)oxy]-L-prolinamide
CAS No.:402957-78-2
Molecular Formula:C41H60N6O10
Molecular Weight:796.9493
Hs Code.:
Mol file:402957-78-2.mol

N-(6-methoxy-6-oxohexanoyl)-L-valyl-L-valyl-(4R)-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-4-[(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)oxy]-L-prolinamide

Synonyms:

Suppliers and Price of N-(6-methoxy-6-oxohexanoyl)-L-valyl-L-valyl-(4R)-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-4-[(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)oxy]-L-prolinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(6-methoxy-6-oxohexanoyl)-L-valyl-L-valyl-(4R)-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-4-[(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)oxy]-L-prolinamide

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.25g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(6-methoxy-6-oxohexanoyl)-L-valyl-L-valyl-(4R)-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-4-[(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)oxy]-L-prolinamide

There total 7 articles about N-(6-methoxy-6-oxohexanoyl)-L-valyl-L-valyl-(4R)-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-4-[(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)oxy]-L-prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-[1-(cyclopropylcarbamoyl-hydroxy-methyl)-butylcarbamoyl]-1-{(S)-2-[(S)-2-(5-methoxycarbonyl-pentanoylamino)-3-methyl-butyrylamino]-3-methyl-butyryl}-pyrrolidin-3-yl ester

: 402957-78-2
3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-(1-cyclopropylaminooxalyl-butylcarbamoyl)-1-{(S)-2-[(S)-2-(5-methoxycarbonyl-pentanoylamino)-3-methyl-butyrylamino]-3-methyl-butyryl}-pyrrolidin-3-yl ester

Guidance literature:: With Dess-Martin periodane;
DOI:10.1016/j.bmcl.2004.05.078

Reference yield:

: 627-91-8
adipic acid monomethyl ester

: 402957-78-2
3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-(1-cyclopropylaminooxalyl-butylcarbamoyl)-1-{(S)-2-[(S)-2-(5-methoxycarbonyl-pentanoylamino)-3-methyl-butyrylamino]-3-methyl-butyryl}-pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: EDCI; DIEA

2: DIEA

3: HOAt; DCC

4: aq. NaOH

5: PyBOP; DIEA

6: Dess-Martin periodinane

With sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; 6: Dess-Martin oxidation;
DOI:10.1016/j.bmcl.2004.05.078

Reference yield:

: 118380-06-6
1-methyl 6-succinimidyl adipate

: 402957-78-2
3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-(1-cyclopropylaminooxalyl-butylcarbamoyl)-1-{(S)-2-[(S)-2-(5-methoxycarbonyl-pentanoylamino)-3-methyl-butyrylamino]-3-methyl-butyryl}-pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: DIEA

2: HOAt; DCC

3: aq. NaOH

4: PyBOP; DIEA

5: Dess-Martin periodinane

With sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; 5: Dess-Martin oxidation;
DOI:10.1016/j.bmcl.2004.05.078