Welcome to LookChem.com Sign In|Join Free

CAS

  • or

627-91-8

Post Buying Request

627-91-8 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

627-91-8 Usage

Description

Monomethyl adipate, a dicarboxylic acid monoester, is the monomethyl ester of adipic acid. It is a clear colorless liquid and serves as a metabolite and a plasticizer. Its unique chemical properties make it a versatile compound with various applications across different industries.

Uses

1. Used in Pharmaceutical Industry:
Monomethyl adipate is used as a synthetic intermediate for the preparation of 1,3,4-thiadiazole hydroxamic acid derivatives. These derivatives exhibit potential antitumor activities, making them valuable in the development of novel cancer treatments.
2. Used in Chemical Synthesis:
In the field of chemical synthesis, Monomethyl adipate is utilized to synthesize mannose-linked biphenylylacetic acid derivatives. These derivatives act as novel inhibitors of selectin-mediated cell adhesion, which can be beneficial in the development of treatments for various diseases and conditions related to cell adhesion.
3. Used in Plastics Industry:
As a plasticizer, Monomethyl adipate is employed in the plastics industry to enhance the flexibility, workability, and durability of various plastic materials. Its ability to improve the properties of plastics makes it a valuable additive in the production of a wide range of plastic products.

Synthesis

According to the general procedure described above, a has been synthesized from adipic acid (730mg, 5 mmol) and methanol (10 ml). Yield: 80%.The synthetic method of Monomethyl adipate mainly contains following three kinds:The one, under alkaline condition or issue the first portion hydrolysis reaction in the catalysis of bioactive enzyme (pork liver lipase etc.) and obtain Monomethyl adipate (such as document Blaise; Koehler; Bulletin de la Societe Chimique deFrance; Vol. (4) 7; (1910); P.219).The 2nd, by hexanodioic acid or adipic anhydride and ethanol, as catalyzer, the control reaction conditions carries out esterification and obtains Monomethyl adipate (such as document Chem.Zentralbl. with acid; Vol.97; (1926; P.126));The 3rd, by the people such as Swann nineteen forty-three with hexanodioic acid, diethylene adipate and ethanol with the condition of acid as catalyst under control reaction conditions obtain monomethyl adipate(document such as Swann; Oehler; Buswell; Org.synth.Coll.Vol.11; (1943); P.227).Synthetic method of monomethyl adipatehttp://www.orgsyn.org/demo.aspx?prep=CV2P0264

Check Digit Verification of cas no

The CAS Registry Mumber 627-91-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 7 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 627-91:
(5*6)+(4*2)+(3*7)+(2*9)+(1*1)=78
78 % 10 = 8
So 627-91-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H12O4/c1-11-7(10)5-3-2-4-6(8)9/h2-5H2,1H3,(H,8,9)/p-1

627-91-8 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (L09061)  Methyl hydrogen adipate, 99%   

  • 627-91-8

  • 5g

  • 389.0CNY

  • Detail
  • Alfa Aesar

  • (L09061)  Methyl hydrogen adipate, 99%   

  • 627-91-8

  • 25g

  • 1128.0CNY

  • Detail

627-91-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name monomethyl adipate

1.2 Other means of identification

Product number -
Other names Monoethyl hexanedioate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Intermediates
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:627-91-8 SDS

627-91-8Synthetic route

2-Carboxy-hexanedioic acid 6-methyl ester
81158-34-1

2-Carboxy-hexanedioic acid 6-methyl ester

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
at 160 - 165℃;100%
hexanedioic acid dimethyl ester
627-93-0

hexanedioic acid dimethyl ester

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
With porcine liver esterase; sodium hydroxide; phosphate buffer for 6h;96%
With sodium hydroxide; phosphate buffer for 1h; Ambient temperature; pig liver esterase;84%
With potassium hydroxide In methanol; diethyl ether; acetonitrile at 0℃; for 54h;71%
methanol
67-56-1

methanol

Adipic acid
124-04-9

Adipic acid

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
With sulfonated poly-divinylbenzene-co-triallylamine at 24.84℃; for 10h;95%
With acid32%
With hydrogenchloride Heating;
With hydrogenchloride In water; toluene at 25 - 85℃; for 8.75h;109.6 g
methyl 6-oxohexanoate
6654-36-0

methyl 6-oxohexanoate

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
95%
With Jones reagent In acetone at 0℃; for 1h; Inert atmosphere;80%
With Iron(III) nitrate nonahydrate; oxygen In acetonitrile at 25℃; under 760.051 Torr; for 12h; Schlenk technique;65%
C7H16O3

C7H16O3

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
With Iron(III) nitrate nonahydrate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium chloride; oxygen In 1,2-dichloro-ethane at 25℃; for 12h;94%
methanol
67-56-1

methanol

Adipic acid
124-04-9

Adipic acid

A

hexanedioic acid dimethyl ester
627-93-0

hexanedioic acid dimethyl ester

B

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
With nickel dichloride for 13h; Heating;A 81%
B 18%
With aluminum oxide at 25℃; for 48h; Reagent/catalyst; Temperature; Time; Green chemistry; chemoselective reaction;A 9%
B 80%
With carbonic acid dimethyl ester at 180℃; under 10343.2 Torr; for 5h; Solvent; Inert atmosphere;A 40%
B 60%
3-iodopropanoic acid
141-76-4

3-iodopropanoic acid

acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
With sodium tetrahydroborate; azobisisobutyronitrile; tributyltin chloride; sodium fluoride Mechanism; 1) EtOH, 20 deg C, 4 h, 2) H2O; other electrophilic olefins;76%
With sodium tetrahydroborate; azobisisobutyronitrile; tributyltin chloride; sodium fluoride 1) EtOH, r.t., 4 h, 2) H2O; Yield given. Multistep reaction;
O-methylcaprolactim
2525-16-8

O-methylcaprolactim

Adipic acid
124-04-9

Adipic acid

A

caprolactam
105-60-2

caprolactam

B

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
at 80 - 85℃; for 16h;A n/a
B 72%
methyl 6-hydroxycaproate
4547-43-7

methyl 6-hydroxycaproate

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
With chromium(VI) oxide; sulfuric acid In water; acetone for 0.666667h; Ambient temperature;46%
hexanedioic acid dimethyl ester
627-93-0

hexanedioic acid dimethyl ester

ethanol
64-17-5

ethanol

A

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

B

diethyl adipate
141-28-6

diethyl adipate

C

adipic acid ethyl methyl ester
18891-13-9

adipic acid ethyl methyl ester

Conditions
ConditionsYield
With water; hydrogen In methanol under 37503.8 Torr;A 11.2%
B 43.5%
C 40.5%
hexanedioic acid dimethyl ester
627-93-0

hexanedioic acid dimethyl ester

A

6-Hydroxyhexanoic acid
1191-25-9

6-Hydroxyhexanoic acid

B

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

C

adipic anhydride
2035-75-8

adipic anhydride

Conditions
ConditionsYield
With hydrogen In 1,4-dioxane under 37503.8 Torr;A 34.1%
B 42.3%
C 21%
2-hydroxy-2-cyclohexen-1-one
10316-66-2

2-hydroxy-2-cyclohexen-1-one

A

1,5-pentanedioic acid
110-94-1

1,5-pentanedioic acid

B

5-oxopentanoic acid
5746-02-1

5-oxopentanoic acid

C

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

D

5,5-dimethoxy-1-oxopentanoic acid
6719-33-1

5,5-dimethoxy-1-oxopentanoic acid

E

methyl 5-carboxy-2-hydroxypentanoate
86544-11-8

methyl 5-carboxy-2-hydroxypentanoate

Conditions
ConditionsYield
With oxygen; methylene blue In methanol at 30℃; for 10h; Product distribution; Irradiation; yield depends on the reaction conditions (temp., sensitizer, solvent);A 7%
B 9%
C 1%
D 23%
E 33%
methanol
67-56-1

methanol

2-hydroxy-2-cyclohexen-1-one
10316-66-2

2-hydroxy-2-cyclohexen-1-one

A

1,5-pentanedioic acid
110-94-1

1,5-pentanedioic acid

B

5-oxopentanoic acid
5746-02-1

5-oxopentanoic acid

C

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane; oxygen; rose bengal at 40℃; for 13h; Irradiation;A 1%
B 5%
C 27%
Adipic acid
124-04-9

Adipic acid

hexanedioic acid dimethyl ester
627-93-0

hexanedioic acid dimethyl ester

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
at 230℃;
for 24h; Heating;35.3 g
In methanol; water
at 160℃; for 24h;
hexanedioic acid dimethyl ester
627-93-0

hexanedioic acid dimethyl ester

A

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

B

methyl 2-oxocyclopentane-1-carboxylate
10472-24-9

methyl 2-oxocyclopentane-1-carboxylate

Conditions
ConditionsYield
With sodium; toluene
Adipic acid
124-04-9

Adipic acid

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
With aluminum oxide In cyclohexane; N,N-dimethyl-formamide Product distribution; study of selectivity of methylation on alumina surface;
C21H38N4NiO2

C21H38N4NiO2

acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
In tetrahydrofuran at 60℃; for 30h;
Adipic acid
124-04-9

Adipic acid

dimethyl sulfate
77-78-1

dimethyl sulfate

A

hexanedioic acid dimethyl ester
627-93-0

hexanedioic acid dimethyl ester

B

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
aluminum oxide In cyclohexane for 2h; Heating; Yield given. Yields of byproduct given;
Adipic acid
124-04-9

Adipic acid

dimethyl sulfate
77-78-1

dimethyl sulfate

A

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

B

Monomethyl phthalate
4376-18-5

Monomethyl phthalate

Conditions
ConditionsYield
aluminum oxide In cyclohexane for 2h; Heating; Yield given. Yields of byproduct given;
methyl 6-oxohexanoate
6654-36-0

methyl 6-oxohexanoate

A

methyl hydrogen succinate
3878-55-5

methyl hydrogen succinate

B

Pentanedioic acid, monomethyl ester
1501-27-5

Pentanedioic acid, monomethyl ester

C

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
With oxygen; H5PV2Mo10O40(1,11) In acetic acid at 60℃; under 750.06 Torr; Yield given. Yields of byproduct given;
methanol
67-56-1

methanol

2-nitrocyclohexanone
4883-67-4

2-nitrocyclohexanone

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
With Oxone; potassium hydroxide; sodium hydroxide; disodium hydrogenphosphate; water 1.) 65 deg C, 4 h, 2.) r.t., 4 h; Yield given. Multistep reaction;
Diesel fuel

Diesel fuel

A

icosane
112-95-8

icosane

B

hepatdecane
629-78-7

hepatdecane

C

n-nonadecane
629-92-5

n-nonadecane

D

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
With air at 1130℃; under 18001.4 Torr; Formation of xenobiotics; high pressure combustion; Further byproducts given. Title compound not separated from byproducts;
biodiesel fuel

biodiesel fuel

A

Methyl linoleate
112-63-0

Methyl linoleate

B

Tridecane
629-50-5

Tridecane

C

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

D

methyl ester of azelaic acid aldehyde
1931-63-1

methyl ester of azelaic acid aldehyde

Conditions
ConditionsYield
With air at 1130℃; under 18001.4 Torr; Formation of xenobiotics; high pressure combustion; Further byproducts given. Title compound not separated from byproducts;
adipic acid (4,5-dimethoxy-2-nitrobenzyl) ester methyl ester
457612-25-8

adipic acid (4,5-dimethoxy-2-nitrobenzyl) ester methyl ester

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
In acetonitrile for 24h; Irradiation; 419 nm irradiation;85 % Spectr.
In acetonitrile for 24h; visible light irradiation;
adipic acid (3',5'-dimethoxybenzoin) ester methyl ester
457612-26-9

adipic acid (3',5'-dimethoxybenzoin) ester methyl ester

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
In acetonitrile for 0.166667h; Irradiation; 254 nm irradiation;95 % Spectr.
In acetonitrile for 0.0833333h; visible light irradiation;
2-methoxycyclohexanol
2979-24-0

2-methoxycyclohexanol

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
With dihydrogen peroxide; Na12[WZn3(H2O)2(ZnW9O34)2] at 75℃; for 7h;
adipic acid mono(4,5-dimethoxy-2-nitrobenzyl) ester
457612-06-5

adipic acid mono(4,5-dimethoxy-2-nitrobenzyl) ester

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 4.9 mg / benzene; ethanol; hexane / 1 h
2: 85 percent Spectr. / acetonitrile / 24 h / Irradiation; 419 nm irradiation
View Scheme
Multi-step reaction with 4 steps
1: 76 percent / 4-(N,N-dimethylamino)pyridine; N,N'-dicyclohexylcarbodiimide / CHCl3 / 24 h / 60 °C
2: 87 percent Spectr. / acetonitrile / 24 h / Irradiation; 419 nm irradiation
3: 5.6 mg / benzene; ethanol; hexane / 1 h
4: 95 percent Spectr. / acetonitrile / 0.17 h / Irradiation; 254 nm irradiation
View Scheme
hexanedioic acid mono-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl] ester

hexanedioic acid mono-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl] ester

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 5.6 mg / benzene; ethanol; hexane / 1 h
2: 95 percent Spectr. / acetonitrile / 0.17 h / Irradiation; 254 nm irradiation
View Scheme
adipic acid (4,5-dimethoxy-2-nitrobenzyl) ester (3',5'-dimethoxybenzoin) ester
457612-13-4

adipic acid (4,5-dimethoxy-2-nitrobenzyl) ester (3',5'-dimethoxybenzoin) ester

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 78 percent Spectr. / acetonitrile / 0.17 h / Irradiation; 254 nm irradiation
2: 4.9 mg / benzene; ethanol; hexane / 1 h
3: 85 percent Spectr. / acetonitrile / 24 h / Irradiation; 419 nm irradiation
View Scheme
Multi-step reaction with 3 steps
1: 87 percent Spectr. / acetonitrile / 24 h / Irradiation; 419 nm irradiation
2: 5.6 mg / benzene; ethanol; hexane / 1 h
3: 95 percent Spectr. / acetonitrile / 0.17 h / Irradiation; 254 nm irradiation
View Scheme
adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

methyl adipoyl chloride
35444-44-1

methyl adipoyl chloride

Conditions
ConditionsYield
With phosphorus pentachloride In diethyl ether Ambient temperature;100%
With thionyl chloride In benzene100%
With oxalyl dichloride for 2h; Heating;94%
adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

N2-[2R-isobutyl-3S-(9-fluorenylmethoxycarbonylamino)-4-hydroxysuccinyl]-L-tert-leucine-N1-methylamide
204126-54-5

N2-[2R-isobutyl-3S-(9-fluorenylmethoxycarbonylamino)-4-hydroxysuccinyl]-L-tert-leucine-N1-methylamide

5-[(1S,2R)-2-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-1-hydroxycarbamoyl-4-methyl-pentylcarbamoyl]-pentanoic acid methyl ester

5-[(1S,2R)-2-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-1-hydroxycarbamoyl-4-methyl-pentylcarbamoyl]-pentanoic acid methyl ester

Conditions
ConditionsYield
Multistep reaction;100%
adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

C40H41NO12
495390-57-3

C40H41NO12

C47H51NO15
495390-58-4

C47H51NO15

Conditions
ConditionsYield
With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline In ethanol for 3h; Heating;100%
adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

tert-butyl (2S)-2-[[(2S)-2-aminopropanoyl]amino]propanoate
2488-26-8

tert-butyl (2S)-2-[[(2S)-2-aminopropanoyl]amino]propanoate

C17H30N2O6

C17H30N2O6

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;100%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;100%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;
adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

N(ε)-benzoyloxycarbonyl-L-lysine tert-butyl ester hydrochloride
5978-22-3

N(ε)-benzoyloxycarbonyl-L-lysine tert-butyl ester hydrochloride

CH3O-Adip-Lys(Z)-OBu-t
93489-31-7

CH3O-Adip-Lys(Z)-OBu-t

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran 1 h, 0 deg C => 6 h, r.t.;99%
biphenyl-2-ylcarbamic acid 1-[2-(methylamino)ethyl]piperidin-4-yl ester
743460-48-2

biphenyl-2-ylcarbamic acid 1-[2-(methylamino)ethyl]piperidin-4-yl ester

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

5-({2-[4-(Biphenyl-2-ylcarbamoyloxy)piperidin-1-yl]ethyl}methylcarbamoyl)pentanoic Acid Methyl Ester
864765-59-3

5-({2-[4-(Biphenyl-2-ylcarbamoyloxy)piperidin-1-yl]ethyl}methylcarbamoyl)pentanoic Acid Methyl Ester

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide for 15h;98%
Trimethyl orthoacetate
1445-45-0

Trimethyl orthoacetate

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

hexanedioic acid dimethyl ester
627-93-0

hexanedioic acid dimethyl ester

Conditions
ConditionsYield
microwave irradiation;96%
adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

phenol
108-95-2

phenol

C13H16O4

C13H16O4

Conditions
ConditionsYield
With magnesium hydroxide; lithium hydroxide monohydrate; di-tert-butyl dicarbonate at 25℃; for 24h; Time;96%
adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

bis(2-tert-butyloxycarbonylaminoethyl)amine
117499-16-8

bis(2-tert-butyloxycarbonylaminoethyl)amine

methyl 6-[bis[2-(tert-butoxycarbonylamino)ethyl]amino]-6-oxohexanoate

methyl 6-[bis[2-(tert-butoxycarbonylamino)ethyl]amino]-6-oxohexanoate

Conditions
ConditionsYield
Stage #1: adipic acid monomethyl ester With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 1h;
Stage #2: bis(2-tert-butyloxycarbonylaminoethyl)amine In dichloromethane at 20℃;
96%
adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

1-dodecylthiol
112-55-0

1-dodecylthiol

C17H32O3S

C17H32O3S

Conditions
ConditionsYield
Stage #1: adipic acid monomethyl ester With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 10℃; for 0.166667h;
Stage #2: 1-dodecylthiol In acetonitrile at 25℃; for 22h;
96%
adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

aniline
62-53-3

aniline

6-oxo-6-(phenylamino)-hexanoic acid methyl ester
64785-82-6

6-oxo-6-(phenylamino)-hexanoic acid methyl ester

Conditions
ConditionsYield
Stage #1: adipic acid monomethyl ester With 1-methyl-1H-imidazole; p-toluenesulfonyl chloride In acetonitrile at 0 - 5℃; for 0.5h;
Stage #2: aniline In acetonitrile at 0 - 5℃; for 2h; Further stages.;
95%
With 1-(tert-butoxy)-2-(tert-butoxy)carbonyl-1,2-dihydroisoquinoline In dichloromethane at 20℃; for 24h;92%
With triethylamine In dichloromethane for 12h; Heating;81%
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxybenzotriazol-hydrate In dichloromethane at 20℃; for 4h;58%
adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

[(glycyl)glycyl]glycine tert-butyl ester
165282-99-5

[(glycyl)glycyl]glycine tert-butyl ester

C17H29N3O7

C17H29N3O7

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃;95%
bis(η5-cyclopentadienyl)ruthenium
1287-13-4

bis(η5-cyclopentadienyl)ruthenium

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

methyl 5-ruthenocenoylpentanoate

methyl 5-ruthenocenoylpentanoate

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; trifluoroacetic anhydride In dichloromethane at 20℃; for 2h; Inert atmosphere; Schlenk technique;95%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

1-methyl 6-succinimidyl adipate
118380-06-6

1-methyl 6-succinimidyl adipate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In acetone at 20℃; for 2h;94%
With dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; Esterification;
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine
With triethylamine In thionyl chloride; dichloromethane
piperidine
110-89-4

piperidine

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

6-oxo-6-(piperidino)-hexanoic acid methyl ester

6-oxo-6-(piperidino)-hexanoic acid methyl ester

Conditions
ConditionsYield
Stage #1: adipic acid monomethyl ester With 1-methyl-1H-imidazole; p-toluenesulfonyl chloride In acetonitrile at 0 - 5℃; for 0.5h;
Stage #2: piperidine In acetonitrile at 0 - 5℃; for 2h; Further stages.;
94%
With 1-(tert-butoxy)-2-(tert-butoxy)carbonyl-1,2-dihydroisoquinoline In dichloromethane at 20℃; for 24h;88%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; Inert atmosphere;82%
adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

1,2,3-trimethoxybenzene
634-36-6

1,2,3-trimethoxybenzene

6-Oxo-6-(2,3,4-trimethoxy-phenyl)-hexanoic acid methyl ester
917591-96-9

6-Oxo-6-(2,3,4-trimethoxy-phenyl)-hexanoic acid methyl ester

Conditions
ConditionsYield
With PPA; Polyphosphoric acid (PPA) at 45℃; for 2.5h;93%
N-p-toluenesulfonylpyrrole
17639-64-4

N-p-toluenesulfonylpyrrole

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

C18H21NO5S
1093430-77-3

C18H21NO5S

Conditions
ConditionsYield
With trifluoroacetic anhydride In dichloromethane for 48h; Reflux; Inert atmosphere;93%
adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

Ala-Thr-Leu-Asn-Phe-OMe trifluoroacetate

Ala-Thr-Leu-Asn-Phe-OMe trifluoroacetate

5-[1-(1-{1-[2-carboxy-1-(1-methoxycarbonyl-2-phenylethylcarbamoyl)ethylcarbamoyl]-3-methylbutylcarbamoyl}-2-hydroxypropylcarbamoyl)ethylcarbamoyl] methyl pentanoate

5-[1-(1-{1-[2-carboxy-1-(1-methoxycarbonyl-2-phenylethylcarbamoyl)ethylcarbamoyl]-3-methylbutylcarbamoyl}-2-hydroxypropylcarbamoyl)ethylcarbamoyl] methyl pentanoate

Conditions
ConditionsYield
With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol In N,N-dimethyl-formamide at 20℃; for 12h;92%
oxalyl dichloride
79-37-8

oxalyl dichloride

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

5-Methoxycarbonylpentansaeure-tert-butylester
52221-08-6

5-Methoxycarbonylpentansaeure-tert-butylester

Conditions
ConditionsYield
With pyridine In N-methyl-acetamide; dichloromethane; tert-butyl alcohol92%
With pyridine In N-methyl-acetamide; dichloromethane; tert-butyl alcohol92%
adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

3-α-acetoxy-4-β-amino-24-norurs-12-ene
108015-89-0

3-α-acetoxy-4-β-amino-24-norurs-12-ene

methyl 6-((3-α-acetoxy-24-norurs-12-en-4-yl)amino)-6-oxohexanoate

methyl 6-((3-α-acetoxy-24-norurs-12-en-4-yl)amino)-6-oxohexanoate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In tetrahydrofuran at 0 - 20℃; for 16.5h;92%
furan
110-00-9

furan

adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

5-(2-Furoyl)pentansaeure-methylester
91971-41-4

5-(2-Furoyl)pentansaeure-methylester

Conditions
ConditionsYield
With boron trifluoride diethyl etherate; trifluoroacetic anhydride In toluene at 0 - 10℃; for 4h; Reagent/catalyst;92%
With boron trifluoride diethyl etherate; trifluoroacetic anhydride In toluene at 0 - 10℃; for 4h; Reagent/catalyst;92%
adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

N-(tert-butoxycarbonyl)-1,4-phenylenediamine
71026-66-9

N-(tert-butoxycarbonyl)-1,4-phenylenediamine

methyl 6-((4-((tert-butoxycarbonyl)amino)phenyl)amino)-6-oxohexanoate

methyl 6-((4-((tert-butoxycarbonyl)amino)phenyl)amino)-6-oxohexanoate

Conditions
ConditionsYield
Stage #1: adipic acid monomethyl ester With 4-methyl-morpholine; chloroformic acid ethyl ester In dichloromethane at 0℃; for 0.25h;
Stage #2: N-(tert-butoxycarbonyl)-1,4-phenylenediamine In dichloromethane at 20℃;
92%
adipic acid monomethyl ester
627-91-8

adipic acid monomethyl ester

N,N''-di-Z-diethylenetriamine
160256-75-7

N,N''-di-Z-diethylenetriamine

C27H35N3O7

C27H35N3O7

Conditions
ConditionsYield
Stage #1: adipic acid monomethyl ester With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 1h;
Stage #2: N,N''-di-Z-diethylenetriamine In dichloromethane at 20℃; for 20h;
91.6%

627-91-8Relevant articles and documents

Oxidation of cyclohexanone and/or cyclohexanol catalyzed by Dawson-type polyoxometalates using hydrogen peroxide

Dermeche, Leila,Idrissou, Yasmina,Mazari, Tassadit,Moudjahed, Mohammed,Rabia, Cherifa

, (2022/03/07)

The oxidation of cyclohexanone, cyclohexanol or cyclohexanone/cyclohexanol mixture using as catalyst, Dawson-type polyoxometalates (POMs) of formula, α- and β-K6P2W18O62, α-K6P2Mo6W12O62 and α1-K7P2Mo5VW12O62 and hydrogen peroxide, carried out at 90 °C with a reaction time of 20 h, led to a high number of mono- and di-acids which were identified by GC-MS. Levulinic, 6-hydroxyhexanoic, adipic, glutaric and succinic acids, major products were evaluated by HPLC. Regardless of the substrate nature, all POMs exhibited high catalytic activity with 94–99% of conversion, whereas the formation of the different products is sensitively related to both the composition and symmetry of the POMs and the substrate nature. The main products are adipic acid in the presence of α-K6P2Mo6W12O62 and α1-K7P2Mo5VW12O62, levulinic acid in the presence of α1-K7P2Mo5VW12O62 and β-K6P2W18O62 and 6-hydroxyhexanoic acid in the presence of α- and β-K6P2W18O62. Graphical abstract: High catalytic activity was observed with?α- and?β-K6P2W18O62, α-K6P2Mo6W12O62 and α1-K7P2Mo5VW12O62 Dawson-type for the oxidation of cyclohexanone, cyclohexanol or cyclohexanone/cyclohexanol mixture, in the hydrogen peroxide presence, to several oxygenated products. Adipic, levulinic and 6-hydroxyhexanoic acids are the main products. The peroxo- species formed in situ could be the active sites.[Figure not available: see fulltext.]

Silica-Mediated Monohydrolysis of Dicarboxylic Esters

Dyker, Gerald

supporting information, p. 6773 - 6776 (2021/12/31)

A new method for the monohydrolysis of dicarboxylic esters is presented, involving as key step a silanolysis at elevated temperatures at the silica gel surface. In the second step, the surface bound silyl esters are cleaved off under mild conditions, giving a straightforward and fast access to half esters. Based on recovered starting material generally yields well above 70 % are achieved, both, with stiff aromatic as well as flexible aliphatic substrates, as long as the ester groups involved are remote enough from each other. Otherwise competing reactions are becoming determinative, anhydride formation in the case of phthalates and decarbonylative fragmentation in the case of malonates. The new method was also successfully tested on a multigram scale with a minimalistic apparatus setup.

NOVEL ESTERIFICATION CATALYST AND USES THEREOF

-

Page/Page column 0026; 0028-0029, (2020/07/07)

Tin (II) glucarate is found to be effective alone and in combination with other tin compounds for catalyzing the reaction of carboxylic acids such as furan-2,5-dicarboxylic acid, terephthalic acid and adipic acid with alcohols such as the C1-C3 alcohols.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 627-91-8