Carbamic acid, [[6-[(1E)-3-amino-3-oxo-1-propenyl]-4-(4-methylphenyl)-2-(2-methylprop yl)-3-quinolinyl]methyl]-, 1,1-dimethylethyl ester

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Chemical Name:Carbamic acid, [[6-[(1E)-3-amino-3-oxo-1-propenyl]-4-(4-methylphenyl)-2-(2-methylprop yl)-3-quinolinyl]methyl]-, 1,1-dimethylethyl ester
CAS No.:660449-19-4
Molecular Formula:C29H35N3O3
Molecular Weight:473.615
Hs Code.:

Synonyms:

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Chemical Property of Carbamic acid, [[6-[(1E)-3-amino-3-oxo-1-propenyl]-4-(4-methylphenyl)-2-(2-methylprop yl)-3-quinolinyl]methyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [[6-[(1E)-3-amino-3-oxo-1-propenyl]-4-(4-methylphenyl)-2-(2-methylprop yl)-3-quinolinyl]methyl]-, 1,1-dimethylethyl ester

There total 15 articles about Carbamic acid, [[6-[(1E)-3-amino-3-oxo-1-propenyl]-4-(4-methylphenyl)-2-(2-methylprop yl)-3-quinolinyl]methyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 660449-18-3
(2E)-3-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]prop-2-enoic acid

: 660449-19-4
tert-butyl ({6-[(1E)-3-amino-3-oxoprop-1-en-1-yl]-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl}methyl)carbamate

Guidance literature:: With N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 17h;
DOI:10.1016/j.bmc.2011.06.032

Reference yield:

: C₂₁H₂₄N₂O

: 660449-19-4
tert-butyl ({6-[(1E)-3-amino-3-oxoprop-1-en-1-yl]-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl}methyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 96 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 20 h / 70 °C / Inert atmosphere

4.1: sodium hydroxide / ethanol; water / 4 h / 60 °C

4.2: 20 °C

5.1: N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 17 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; N-hydroxybenzotriazole ammonium salt; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; mineral oil; 3.1: Heck reaction;
DOI:10.1016/j.bmc.2011.06.032

Reference yield:

: 660449-17-2
ethyl (2E)-3-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]prop-2-enoate

: 660449-19-4
tert-butyl ({6-[(1E)-3-amino-3-oxoprop-1-en-1-yl]-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl}methyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol; water / 4 h / 60 °C

1.2: 20 °C

2.1: N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 17 h / 20 °C

With N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.06.032