2-Propenoic acid, 3-[3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-4-(4-methylphenyl)-2- (2-methylpropyl)-6-quinolinyl]-, ethyl ester, (2E)-

Base Information

Chemical Name:2-Propenoic acid, 3-[3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-4-(4-methylphenyl)-2- (2-methylpropyl)-6-quinolinyl]-, ethyl ester, (2E)-
CAS No.:660449-17-2
Molecular Formula:C31H38N2O4
Molecular Weight:502.654
Hs Code.:

2-Propenoic acid,
3-[3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-4-(4-methylphenyl)-2-
(2-methylpropyl)-6-quinolinyl]-, ethyl ester, (2E)-

Synonyms:

Suppliers and Price of 2-Propenoic acid, 3-[3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-4-(4-methylphenyl)-2- (2-methylpropyl)-6-quinolinyl]-, ethyl ester, (2E)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Propenoic acid, 3-[3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-4-(4-methylphenyl)-2- (2-methylpropyl)-6-quinolinyl]-, ethyl ester, (2E)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-Propenoic acid, 3-[3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-4-(4-methylphenyl)-2- (2-methylpropyl)-6-quinolinyl]-, ethyl ester, (2E)-

There total 17 articles about 2-Propenoic acid, 3-[3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-4-(4-methylphenyl)-2- (2-methylpropyl)-6-quinolinyl]-, ethyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 660449-04-7
tert-butyl {[6-hydroxy-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate

: 660449-17-2
ethyl (2E)-3-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]prop-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

1.2: 0.5 h / 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 6 h / 70 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium hydride; triethylamine; In N,N-dimethyl-formamide; mineral oil; 2.1: Heck reaction;
DOI:10.1021/jm101236h

Reference yield:

: 64373-43-9
5-methyl-3-oxo-hexanenitrile

: 660449-17-2
ethyl (2E)-3-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]prop-2-enoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: methanesulfonic acid / toluene / 17 h / Reflux

2.1: palladium diacetate; 2,2'-bis(diphenylphosphino)biphenyl / tert-butyl alcohol / 15 h / 70 °C / Inert atmosphere

3.1: trifluoroacetic acid / tetrahydrofuran / 4 h / 20 °C

4.1: ammonia; hydrogen / tetrahydrofuran; methanol / 8 h / 70 °C / 3750.38 Torr

5.1: tetrahydrofuran / 3 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

6.2: 0.5 h / 20 °C

7.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 6 h / 70 °C

With bis-triphenylphosphine-palladium(II) chloride; methanesulfonic acid; ammonia; hydrogen; palladium diacetate; sodium hydride; 2,2'-bis(diphenylphosphino)biphenyl; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; mineral oil; tert-butyl alcohol; 7.1: Heck reaction;
DOI:10.1021/jm101236h

Reference yield:

: 556-24-1
methyl 3-methylbutanoate

: 660449-17-2
ethyl (2E)-3-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]prop-2-enoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 15 h / 70 °C

2.1: methanesulfonic acid / toluene / 17 h / Reflux

3.1: palladium diacetate; 2,2'-bis(diphenylphosphino)biphenyl / tert-butyl alcohol / 15 h / 70 °C / Inert atmosphere

4.1: trifluoroacetic acid / tetrahydrofuran / 4 h / 20 °C

5.1: ammonia; hydrogen / tetrahydrofuran; methanol / 8 h / 70 °C / 3750.38 Torr

6.1: tetrahydrofuran / 3 h / 20 °C

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

7.2: 0.5 h / 20 °C

8.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 6 h / 70 °C

With bis-triphenylphosphine-palladium(II) chloride; methanesulfonic acid; ammonia; hydrogen; palladium diacetate; sodium hydride; 2,2'-bis(diphenylphosphino)biphenyl; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; mineral oil; tert-butyl alcohol; 8.1: Heck reaction;
DOI:10.1021/jm101236h