1-Azabicyclo[2.2.2]octane-2-carbonyl chloride;hydrochloride

Base Information

• Chemical Name: 1-Azabicyclo[2.2.2]octane-2-carbonyl chloride;hydrochloride
• CAS No.: 66073-49-2
• Molecular Formula: C8H12ClNO.ClH
• Molecular Weight: 210.103
• DSSTox Substance ID: DTXSID50480919

Synonyms:66073-49-2;SCHEMBL6990898;DTXSID50480919;1-Azabicyclo[2.2.2]octane-2-carbonyl chloride--hydrogen chloride (1/1)

Chemical Property of 1-Azabicyclo[2.2.2]octane-2-carbonyl chloride;hydrochloride

Chemical Property:

• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 209.0374194
• Heavy Atom Count: 12
• Complexity: 175

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CN2CCC1CC2C(=O)Cl.Cl

Technology Process of 1-Azabicyclo[2.2.2]octane-2-carbonyl chloride;hydrochloride

There total 1 articles about 1-Azabicyclo[2.2.2]octane-2-carbonyl chloride;hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

quinuiclidine-2-carboxylic acid hydrochloride (52601-23-7,94160-98-2,52730-01-5) → quinuiclidine-2-carbonyl chloride hydrochloride (66073-49-2)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide; for 24h;

DOI:10.1021/jm00176a014

Reference yield: 84.4%

4-trifluoromethylphenylamine (455-14-1) + quinuiclidine-2-carbonyl chloride hydrochloride (66073-49-2) → 1-Aza-bicyclo[2.2.2]octane-2-carboxylic acid (4-trifluoromethyl-phenyl)-amide

Guidance literature:

With triethylamine; In benzene; 1.) 55 deg C, 1.5 h, 2.) reflux, 15 min;

Reference yield: 76.2%

quinuiclidine-2-carbonyl chloride hydrochloride (66073-49-2) + para-fluorobenzylamine (140-75-0) → 1-Aza-bicyclo[2.2.2]octane-2-carboxylic acid 4-fluoro-benzylamide

Guidance literature:

With triethylamine; In benzene; 1.) 55 deg C, 1.5 h, 2.) reflux, 15 min;

upstream raw materials:

quinuiclidine-2-carboxylic acid hydrochloride

Downstream raw materials:

(+/-)-ethyl quinuclidine-2-carboxylate

(1-Aza-bicyclo[2.2.2]oct-2-yl)-(4-p-tolyl-piperazin-1-yl)-methanone

(1-Aza-bicyclo[2.2.2]oct-2-yl)-[4-(4-chloro-phenyl)-piperazin-1-yl]-methanone

(1-Aza-bicyclo[2.2.2]oct-2-yl)-[4-(4-methoxy-phenyl)-piperazin-1-yl]-methanone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 66073-49-2 1-Azabicyclo[2.2.2]octane-2-carbonyl chloride, hydrochloride

Send

Send

Metric Ton KG G Pound L ML

Send

Send