(2-BROMO-4-FLUOROPHENYL)BENZYL ETHER

Base Information

• Chemical Name: (2-BROMO-4-FLUOROPHENYL)BENZYL ETHER
• CAS No.: 660842-05-7
• Molecular Formula: C13H10BrFO
• Molecular Weight: 281.124
• Mol file: 660842-05-7.mol

Synonyms:Benzene,2-bromo-4-fluoro-1-(phenylmethoxy);benzyl 2-bromo-4-fluorophenyl ether;2-BROMO-4-FLUOROPHENYL BENZYL ETHER;1-(benzyloxy)-2-bromo-4-fluorobenzene;

Chemical Property of (2-BROMO-4-FLUOROPHENYL)BENZYL ETHER

Chemical Property:

• PSA: 9.23000
• LogP: 4.16720

Purity/Quality:

95% ^*data from raw suppliers

1-Bromo-2-benzyloxy-5-fluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-BROMO-4-FLUOROPHENYL)BENZYL ETHER

There total 3 articles about (2-BROMO-4-FLUOROPHENYL)BENZYL ETHER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.5%

→ 1-(benzyloxy)-2-bromo-4-fluorobenzene (660842-05-7)

Guidance literature:

Reference yield: 90.0%

2-bromo-4-fluoro-phenol (496-69-5) + benzyl bromide (100-39-0) → 1-(benzyloxy)-2-bromo-4-fluorobenzene (660842-05-7)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In DMF (N,N-dimethyl-formamide); aqueous sodium chloride; at 20 ℃; for 1.5h;

Reference yield:

2-bromo-4-fluoro-1-methoxybenzene (452-08-4) → 1-(benzyloxy)-2-bromo-4-fluorobenzene (660842-05-7)

Guidance literature:

Multi-step reaction with 2 steps

1: boron tribromide / dichloromethane / 2 h / -78 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C

With boron tribromide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ol202473w

upstream raw materials:

2-bromo-4-fluoro-phenol

benzyl bromide

2-bromo-4-fluoro-1-methoxybenzene

Downstream raw materials:

2-benzyloxy-5-fluoro-(4'-ethyl)diphenylmethanol

(S)-4-fluoro-2-(2-hydroxypropyl)phenol

(R)-(-)-1-[2-(benzyloxy)-5-fluorophenyl]propan-2-yl acetate

(S)-(+)-1-[2-(benzyloxy)-5-fluorophenyl]propan-2-ol

Refernces

• 1、 -. "MACROCYCLIC COMPOUNDS AS KINASES INHIBITORS AND USES THEREOF". Page/Page column 45-46. . Retrieved 2021/10/15.
• 2、 -. "RADIOLABELLED mGLuR2 PET LIGANDS". Page/Page column 37. . Retrieved 2012/05/31.