5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde

Base Information

Chemical Name:5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde
CAS No.:660845-30-7
Molecular Formula:C6H5ClF2N2O
Molecular Weight:194.568
Hs Code.:2933199090
DSSTox Substance ID:DTXSID20599562
Wikidata:Q82495459
Mol file:660845-30-7.mol

Synonyms:5-CHLORO-3-(DIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBALDEHYDE;660845-30-7;5-CHLORO-3-(DIFLUOROMETHYL)-1-METHYLPYRAZOLE-4-CARBALDEHYDE;MFCD12827692;1H-Pyrazole-4-carboxaldehyde, 5-chloro-3-(difluoromethyl)-1-methyl-;C6H5ClF2N2O;SCHEMBL440614;DTXSID20599562;AMY33070;AKOS012178212;SB18299;s11507;AC-27617;DS-16687;SY102715;DB-073706;CS-0044325;EN300-3007887;A867526;Z1033282900;5-chloro-1-methyl-3-difluoromethyl-1H-pyrazole-4-carbaldehyde;5-chloro-3-difluoromethyl-1-methyl-1H-pyrazole-4-carboaldehyde

Suppliers and Price of 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxaldehyde
1g
$ 200.00

Crysdot
5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde 98%
5g
$ 267.00

Crysdot
5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde 98%
10g
$ 416.00

Chemenu
5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde 95+%
5g
$ 282.00

Chemenu
5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde 95+%
25g
$ 1188.00

Chemenu
5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde 95+%
10g
$ 554.00

Chemenu
5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde 95+%
1g
$ 109.00

Apolloscientific
5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde 98%
1g
$ 85.00

American Custom Chemicals Corporation
5-CHLORO-3-(DIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBALDEHYDE 95.00%
5MG
$ 496.16

Alichem
5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde
10g
$ 364.17

Total 39 raw suppliers

Chemical Property of 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde

Chemical Property:

Boiling Point:271.7±40.0 °C(Predicted)
PKA:-3.18±0.10(Predicted)
PSA：34.89000
Density:1.52±0.1 g/cm3(Predicted)
LogP:1.82360
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:1.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:194.0058468
Heavy Atom Count:12
Complexity:181

Purity/Quality:

97% ^*data from raw suppliers

5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxaldehyde ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C(=C(C(=N1)C(F)F)C=O)Cl
Uses 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxaldehyde is patented as a reactant in the preparation of pyrazole amide compounds for use as antifungal agents.

Technology Process of 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde

There total 7 articles about 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.2%

: 5-(difluoromethyl)-2-methyl-2,4-dihydro-3H-pyrazol-3-one

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 660845-30-7
5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde

Guidance literature:: With trichlorophosphate; at 120 ℃; for 0.666667h; Cooling with ice;

Reference yield: 73.3%

: 129922-58-3
1-methyl-3-difluoromethyl-5-hydroxy-1H-pyrazole

: 660845-30-7
5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde

Guidance literature:: With trichlorophosphate; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 4h;

Reference yield: 72.0%

: 129922-58-3
1-methyl-3-difluoromethyl-5-hydroxy-1H-pyrazole

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 660845-30-7
5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde

Guidance literature:: 1-methyl-3-difluoromethyl-5-hydroxy-1H-pyrazole; N,N-dimethyl-formamide; With trichlorophosphate; In toluene; for 3h; Cooling; Reflux;

With sodium hydrogencarbonate; In water; ethyl acetate;