2-Azabicyclo[2.2.2]octane-5-carboxylic acid, 7,8-bis(acetyloxy)-4-(methoxymethoxy)-3-oxo-2-(phenylmethyl)-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1R,4R,5S,7S,8R)-

Base Information

Chemical Name:2-Azabicyclo[2.2.2]octane-5-carboxylic acid, 7,8-bis(acetyloxy)-4-(methoxymethoxy)-3-oxo-2-(phenylmethyl)-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1R,4R,5S,7S,8R)-
CAS No.:660849-34-3
Molecular Formula:C37H47NO9
Molecular Weight:649.781
Hs Code.:

2-Azabicyclo[2.2.2]octane-5-carboxylic acid,
7,8-bis(acetyloxy)-4-(methoxymethoxy)-3-oxo-2-(phenylmethyl)-,
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester,
(1R,4R,5S,7S,8R)-

Synonyms:

Suppliers and Price of 2-Azabicyclo[2.2.2]octane-5-carboxylic acid, 7,8-bis(acetyloxy)-4-(methoxymethoxy)-3-oxo-2-(phenylmethyl)-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1R,4R,5S,7S,8R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Azabicyclo[2.2.2]octane-5-carboxylic acid, 7,8-bis(acetyloxy)-4-(methoxymethoxy)-3-oxo-2-(phenylmethyl)-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1R,4R,5S,7S,8R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Azabicyclo[2.2.2]octane-5-carboxylic acid, 7,8-bis(acetyloxy)-4-(methoxymethoxy)-3-oxo-2-(phenylmethyl)-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1R,4R,5S,7S,8R)-

There total 2 articles about 2-Azabicyclo[2.2.2]octane-5-carboxylic acid, 7,8-bis(acetyloxy)-4-(methoxymethoxy)-3-oxo-2-(phenylmethyl)-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1R,4R,5S,7S,8R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 3396-11-0
cesium acetate

: 660849-30-9
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R,4R,5S,7R,8R)-8-acetoxy-2-benzyl-4-(methoxymethoxy)-3-oxo-7-[(trifluoromethyl)sulfonyloxy]-2-azabicyclo[2.2.2]octane-5-carboxylate

: 660849-34-3
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R,4R,5S,7S,8R)-7,8-diacetoxy-2-benzyl-4-(methoxymethoxy)-3-oxo-2-azabicyclo[2.2.2]octane-5-carboxylate

Guidance literature:: In N,N-dimethyl-formamide; at 80 ℃; for 2.5h;
DOI:10.1002/hlca.200390321

Reference yield:

: 660849-28-5
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R,4R,5S,7R,8R)-2-benzyl-7,8-dihydroxy-4-(methoxymethoxy)-3-oxo-2-azabicyclo[2.2.2]octane-5-carboxylate

: 660849-34-3
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R,4R,5S,7S,8R)-7,8-diacetoxy-2-benzyl-4-(methoxymethoxy)-3-oxo-2-azabicyclo[2.2.2]octane-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: CH₂Cl₂; pyridine / 12 h / 24 °C

1.2: 81 percent / CH₂Cl₂; pyridine / 4 h / 25 Torr

2.1: 94 percent / dimethylformamide / 2.5 h / 80 °C

In pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200390321

Reference yield: 88.0%

: 108-24-7
acetic anhydride

: 660849-34-3
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R,4R,5S,7S,8R)-7,8-diacetoxy-2-benzyl-4-(methoxymethoxy)-3-oxo-2-azabicyclo[2.2.2]octane-5-carboxylate

: 200432-36-6
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl acetate

: 660849-36-5
(1R,4R,5S,7S,8R)-7,8-diacetoxy-2-benzyl-4-(methoxymethoxy)-2-azabicyclo[2.2.2]octane-5-methyl acetate

Guidance literature:: (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R,4R,5S,7S,8R)-7,8-diacetoxy-2-benzyl-4-(methoxymethoxy)-3-oxo-2-azabicyclo[2.2.2]octane-5-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; for 5h; Heating;

acetic anhydride; With pyridine; dmap; at 24 ℃; for 12h;
DOI:10.1002/hlca.200390321