Baccatin V

Base Information

• Chemical Name: Baccatin V
• CAS No.: 31077-81-3
• Molecular Formula: C31H38 O11
• Molecular Weight: 586.636
• Mol file: 31077-81-3.mol

Synonyms:7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one,6,12b-bis(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,9,11-trihydroxy-4a,8,13,13-tetramethyl-,[2aR-(2aa,4a,4ab,6b,9a,11a,12a,12aa,12ba)]-; Tax-11-en-9-one, 5b,20-epoxy-1,2a,4,7a,10b,13a-hexahydroxy-, 4,10-diacetate 2-benzoate (8CI); 7-Epibaccatin III;7-epi-baccatin III; Baccatin V

Chemical Property of Baccatin V

Chemical Property:

• Boiling Point: 713.6±60.0 °C(Predicted)
• PKA: 12.76±0.70(Predicted)
• PSA: 165.89000
• Density: 1.38±0.1 g/cm3(Predicted)
• LogP: 1.65260

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Baccatin V

There total 14 articles about Baccatin V which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

10-desacetylbaccatin III (32981-86-5,71629-92-0,92999-93-4,115509-92-7,172018-16-5) + acetic anhydride (108-24-7) → baccatin III (27548-93-2,31077-81-3)

Guidance literature:

cerium(III) chloride; at 20 ℃; for 1.5h;

Reference yield: 96.0%

acetic anhydride (108-24-7) + 10-deacetyl-7-epi-baccatin III (71629-92-0,172018-16-5) → 7-epi-baccatine III (31077-81-3)

Guidance literature:

With cerium(III) chloride heptahydrate; In tetrahydrofuran; at 0 - 20 ℃; for 5h;

DOI:10.1016/j.ejmech.2018.07.029

Reference yield: 78.8%

taxol (33069-62-4) → 7-epi-baccatin III (31077-81-3) + baccatin III (27548-93-2)

Guidance literature:

With sodium tetrahydroborate; phosphate buffer; In tetrahydrofuran; for 1.16667h; Ambient temperature;

DOI:10.1002/jlcr.2580341010

upstream raw materials:

methanol

Cephalomannine

baccatin III

7-epipaclitaxel

Refernces

• 1、 Ren, Sumei,Wang, Yujie,Wang, Junfei,Gao, Dingding,Zhang, Minmin,Ding, Ning,Li, Yingxia. "Synthesis and biological evaluation of novel larotaxel analogues". . p. 692 - 710. Retrieved 2018/07/29.
• 2、 -. "Method for preparing 7-epi-taxane compounds". Paragraph 0068-0070. . Retrieved 2017/03/14.