Imidazo[1,2-a]pyrazine

Base Information

• Chemical Name: Imidazo[1,2-a]pyrazine
• CAS No.: 274-79-3
• Molecular Formula: C6H5N3
• Molecular Weight: 119.12
• Hs Code.: 2933990090
• European Community (EC) Number: 636-673-8
• DSSTox Substance ID: DTXSID30378007
• Nikkaji Number: J848.047H
• Wikidata: Q27117291
• Metabolomics Workbench ID: 55704
• ChEMBL ID: CHEMBL63446
• Mol file: 274-79-3.mol

Synonyms:imidazo(1,2-a)pyrazine

Chemical Property of Imidazo[1,2-a]pyrazine

Chemical Property:

• Melting Point: 90-94 °C
• Refractive Index: 1.689
• PKA: 4.30±0.30(Predicted)
• PSA: 30.19000
• Density: 1.29 g/cm³
• LogP: 0.72930
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 119.048347172
• Heavy Atom Count: 9
• Complexity: 105

Purity/Quality:

97% ^*data from raw suppliers

Imidazo[1,2-a]pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CN2C=CN=C2C=N1

Technology Process of Imidazo[1,2-a]pyrazine

There total 5 articles about Imidazo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Aminopyrazine (5049-61-6) + 2-chloroethanal (107-20-0) → imidazo[1,2-a]pyrazine (274-79-3)

Guidance literature:

at 70 ℃;

DOI:10.1021/acs.jmedchem.0c02064

Reference yield: 94.0%

2-Aminopyrazine (5049-61-6) + Bromoacetaldehyde diethyl acetal (2032-35-1) → imidazo[1,2-a]pyrazine (274-79-3)

Guidance literature:

With hydrogen bromide; In ethanol; water; at 70 - 80 ℃; for 17h;

Reference yield: 94.0%

→ imidazo[1,2-a]pyrazine (274-79-3)

Guidance literature:

upstream raw materials:

2-Aminopyrazine

2-chloroethanal

Bromoacetaldehyde diethyl acetal

1-bromo-2,2-dimethoxyethane

Downstream raw materials:

8-phenylimidazo<1,2-a>pyrazine

3-formylimidazo<1,2-a>pyrazine

3-hydroxymethylimidazo<1,2-a>pyrazine

3-iodoimidazo[1,2-a]pyrazine