2-Aminopyrazine

Base Information

• Chemical Name: 2-Aminopyrazine
• CAS No.: 5049-61-6
• Molecular Formula: C4H5N3
• Molecular Weight: 95.1038
• Hs Code.: 29339990
• European Community (EC) Number: 225-748-7
• NSC Number: 13147
• UNII: ES73FRK6MY
• DSSTox Substance ID: DTXSID80198510
• Nikkaji Number: J80.944F
• Wikidata: Q72441381
• ChEMBL ID: CHEMBL1834089
• Mol file: 5049-61-6.mol

Synonyms:2-aminopyrazine

Chemical Property of 2-Aminopyrazine

Chemical Property:

• Appearance/Colour: slightly yellow to beige crystalline powder
• Vapor Pressure: 0.021mmHg at 25°C
• Melting Point: 118-120 °C(lit.)
• Refractive Index: 1.598
• Boiling Point: 250.905 °C at 760 mmHg
• PKA: 3.22±0.10(Predicted)
• Flash Point: 129.08 °C
• PSA: 51.80000
• Density: 1.217 g/cm³
• LogP: 0.64000
• Storage Temp.: Flammables area
• Solubility.: soluble in Methanol
• Water Solubility.: soluble
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 95.048347172
• Heavy Atom Count: 7
• Complexity: 54.9

Purity/Quality:

99% ^*data from raw suppliers

2-Aminopyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, F
• Hazard Codes: Xi,F
• Statements: 36/37/38-11
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C=N1)N
• Uses: 2-Aminopyrazine acts as a raw material in a four-component synthesis of imidazolidines. It is also used as an intermediate in synthetic chemistry. In addition, 2-aminopyrazine can be reacted with α-ketohydroximoyl chlorides to form 3-nitrosoimidazo[1,2-a]pyrazines.

Technology Process of 2-Aminopyrazine

There total 24 articles about 2-Aminopyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-iodopyrazine (32111-21-0) → 2-Aminopyrazine (5049-61-6)

Guidance literature:

With copper(I) oxide; ammonia; potassium carbonate; In 1,4-dioxane; at 140 ℃; for 16h; under 7757.43 Torr;

DOI:10.14233/ajchem.2020.22365

Reference yield: 87.0%

2-amino-3,5-dibromopyrazine (24241-18-7) → 2-Aminopyrazine (5049-61-6) + 5-amino-2-bromopyrazine (59489-71-3)

Guidance literature:

With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In dimethyl sulfoxide; regioselective reaction;

DOI:10.1021/op0600963

Reference yield: 82.6%

2-pyrazine carbonitrile (19847-12-2) → 2-Aminopyrazine (5049-61-6)

Guidance literature:

With sodium hypochlorite; sodium hydroxide; at 20 - 60 ℃; for 5h;

upstream raw materials:

2-chloropyrazin

pyrazinamide

3-aminopyrazinoic acid

Lumazine

Downstream raw materials:

4-hydroxy-benzenesulfonic acid pyrazin-2-ylamide

1-(pyrazin-2-yl)thiourea

N-(4-(N-(pyrazin-2-yl)sulfamoyl)phenyl)acetamide

pyrazin-2(1H)-one