4-phenyl-2H-pyrido[1,2-a]pyrimidin-2-one

Base Information

• Chemical Name: 4-phenyl-2H-pyrido[1,2-a]pyrimidin-2-one
• CAS No.: 66156-19-2
• Molecular Formula: C14H10N2O
• Molecular Weight: 222.246
• European Community (EC) Number: 663-516-0
• Nikkaji Number: J1.892.792F
• Mol file: 66156-19-2.mol

Synonyms:4-phenyl-2H-pyrido[1,2-a]pyrimidin-2-one;66156-19-2;SCHEMBL9616068;AHPOSBFUSLSSMD-UHFFFAOYSA-N;STK690108;AKOS003002254;4-Phenyl-2H-pyrido[1,2-a]pyrimidine-2-one;2H-Pyrido[1,2-a]pyrimidin-2-one, 4-phenyl-

Chemical Property of 4-phenyl-2H-pyrido[1,2-a]pyrimidin-2-one

Chemical Property:

• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 222.079312947
• Heavy Atom Count: 17
• Complexity: 451

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC(=O)N=C3N2C=CC=C3

Technology Process of 4-phenyl-2H-pyrido[1,2-a]pyrimidin-2-one

There total 5 articles about 4-phenyl-2H-pyrido[1,2-a]pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2-aminopyridine (504-29-0) + ethyl 3-oxo-3-phenylpropionate (94-02-0) → 4-phenyl-2H-pyrido [1,2-a]pyrimidine-2-one (66156-19-2)

Guidance literature:

With sulfur; at 120 ℃; for 5h; Green chemistry;

DOI:10.1002/ejoc.201901356

Reference yield: 21.0%

2-aminopyridine (504-29-0) + phenylpropynoic acid ethyl ester (2216-94-6) → 4-phenyl-2H-pyrido [1,2-a]pyrimidine-2-one (66156-19-2) + diethyl 2,5-diphenyl-1-(pyridin-2-yl)-1H-pyrrole-3,4-dicarboxylate (1393658-25-7) + 2-ethoxycarbonyl-3-phenylimidazo<1,2-a>pyridine (119448-81-6)

Guidance literature:

With oxygen; copper diacetate; palladium diacetate; Trimethylacetic acid; In N,N-dimethyl-formamide; at 110 ℃; for 24h;

DOI:10.1021/ol301858j

Reference yield:

2-aminopyridine (504-29-0) + phenylpropynoic acid ethyl ester (2216-94-6) → 4-phenyl-2H-pyrido [1,2-a]pyrimidine-2-one (66156-19-2)

Guidance literature:

In ethanol; at 20 ℃;

DOI:10.1016/S0040-4039(03)00700-7

upstream raw materials:

N-(pyridin-2-yl)-3-oxo-3-phenylpropanamide

sulfuric acid

2-aminopyridine

phenylpropynoic acid ethyl ester