6-Hydroxykaempferol

Base Information

• Chemical Name: 6-Hydroxykaempferol
• CAS No.: 4324-55-4
• Molecular Formula: C15H10O7
• Molecular Weight: 302.24
• Mol file: 4324-55-4.mol

Synonyms:6-Hydroxy-kaempferol;3,5,6,7,4'-Pentahydroxy-flaven-4-on;3,4',5,6,7-pentahydroxyflavone;

Chemical Property of 6-Hydroxykaempferol

Chemical Property:

• Vapor Pressure: 7.92E-19mmHg at 25°C
• Melting Point: 310-315 °C (decomp)
• Boiling Point: 669.3°Cat760mmHg
• PKA: 6.15±0.40(Predicted)
• Flash Point: 258.4°C
• PSA: 131.36000
• Density: 1.799g/cm³
• LogP: 1.98800

Purity/Quality:

Analysis control,HPLC≥95% ^*data from raw suppliers

6-Hydroxykaempferol ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Hydroxykaempferol

There total 14 articles about 6-Hydroxykaempferol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

3-hydroxy-5,6,7,4'-tetramethoxymethoxyflavone (5867-71-0) → 3,4',5,6,7-pentahydroxyflavone (4324-55-4)

Guidance literature:

With boron tribromide; In dichloromethane; at -80 - 20 ℃; for 13h;

DOI:10.3390/12010086

Reference yield:

3,4,5-trimethoxyphenol (642-71-7) → 3,4',5,6,7-pentahydroxyflavone (4324-55-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 96 percent / AcONa / 3 h / 110 °C

2: 94 percent / BF₃*Et₂O / 2 h / 70 °C

3: 89 percent / KOH / ethanol / 0 - 20 °C

4: 74 percent / iodine / dimethylsulfoxide / 2 h / 190 - 200 °C

5: 58 percent / BBr₃ / CH₂Cl₂ / 13 h / -80 - 20 °C

With potassium hydroxide; boron trifluoride diethyl etherate; iodine; sodium acetate; boron tribromide; In ethanol; dichloromethane; dimethyl sulfoxide;

DOI:10.3390/12010086

Reference yield:

6-hydroxy-2,3,4-trimethoxyacetophenone (22248-14-2) → 3,4',5,6,7-pentahydroxyflavone (4324-55-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 89 percent / KOH / ethanol / 0 - 20 °C

2: 74 percent / iodine / dimethylsulfoxide / 2 h / 190 - 200 °C

3: 58 percent / BBr₃ / CH₂Cl₂ / 13 h / -80 - 20 °C

With potassium hydroxide; iodine; boron tribromide; In ethanol; dichloromethane; dimethyl sulfoxide;

DOI:10.3390/12010086

upstream raw materials:

6-hydroxy-3,5,7-trimethoxy-2-(4-methoxy-phenyl)-chromen-4-one

3-hydroxy-5,6,7,4'-tetramethoxymethoxyflavone

5,6-dihydroxy-3,7,4′-trimethoxyflavonol

3,4,5-trimethoxyphenol

Refernces

• 1、 Williams,Hoult,Harborne,Greenham,Eagles. "A biologically active lipophilic flavonol from Tanacetum parthenium". . p. 267 - 270. Retrieved 2007/10/02.