3-hydroxy-5,6,7,4'-tetramethoxymethoxyflavone

Base Information

• Chemical Name: 3-hydroxy-5,6,7,4'-tetramethoxymethoxyflavone
• CAS No.: 5867-71-0
• Molecular Formula: C₁₉H₁₈O₇
• Molecular Weight: 358.348
• Mol file: 5867-71-0.mol

Synonyms:3-hydroxy-5,6,7,4'-tetramethoxymethoxyflavone

Chemical Property of 3-hydroxy-5,6,7,4'-tetramethoxymethoxyflavone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-hydroxy-5,6,7,4'-tetramethoxymethoxyflavone

There total 8 articles about 3-hydroxy-5,6,7,4'-tetramethoxymethoxyflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

5,6,7,4'-tetramethoxyflavone (1168-42-9) → 3-hydroxy-5,6,7,4'-tetramethoxymethoxyflavone (5867-71-0)

Guidance literature:

Multistep reaction.;

DOI:10.3390/12010086

Reference yield:

3,4,5-trimethoxyphenol (642-71-7) → 3-hydroxy-5,6,7,4'-tetramethoxymethoxyflavone (5867-71-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 96 percent / AcONa / 3 h / 110 °C

2: 94 percent / BF₃*Et₂O / 2 h / 70 °C

3: 89 percent / KOH / ethanol / 0 - 20 °C

4: 74 percent / iodine / dimethylsulfoxide / 2 h / 190 - 200 °C

With potassium hydroxide; boron trifluoride diethyl etherate; iodine; sodium acetate; In ethanol; dimethyl sulfoxide;

DOI:10.3390/12010086

Reference yield:

6-hydroxy-2,3,4-trimethoxyacetophenone (22248-14-2) → 3-hydroxy-5,6,7,4'-tetramethoxymethoxyflavone (5867-71-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / KOH / ethanol / 0 - 20 °C

2: 74 percent / iodine / dimethylsulfoxide / 2 h / 190 - 200 °C

With potassium hydroxide; iodine; In ethanol; dimethyl sulfoxide;

DOI:10.3390/12010086

upstream raw materials:

5,6,7,4'-tetra methoxyl-flavanone

5,6,7,4'-tetramethoxyflavone

3,4,5-trimethoxyphenol

6-hydroxy-2,3,4-trimethoxyacetophenone

Downstream raw materials:

3,5,6,7,4'-pentamethoxyflavone

3,4',5,6,7-pentahydroxyflavone