L-701,252

Base Information

• Chemical Name: L-701,252
• CAS No.: 151057-13-5
• Molecular Formula: C₁₃H₁₀ClNO₃
• Molecular Weight: 263.68
• Mol file: 151057-13-5.mol

Synonyms:L 701252;7-Chloro-3-(cyclopropylcarbonyl)-2-hydroxyquinolin-4(1H)-one;Methanone, (7-chloro-2,4-dihydroxy-3-quinolinyl)cyclopropyl-;(7-Chloro-2,4-dihydroxyquinolin-3-yl)(cyclopropyl)methanone;

Chemical Property of L-701,252

Chemical Property:

• Appearance/Colour: White crystalline solid
• Vapor Pressure: 2.03E-08mmHg at 25°C
• Refractive Index: 1.694
• Boiling Point: 437.3 °C at 760 mmHg
• Flash Point: 218.3 °C
• PSA: 70.16000
• Density: 1.573 g/cm³
• LogP: 2.47980
• Storage Temp.: Desiccate at +4°C

Purity/Quality:

97% ^*data from raw suppliers

L-701,252 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-701,252

There total 3 articles about L-701,252 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Chloro-2-(3-cyclopropyl-3-oxo-propionylamino)-benzoic acid ethyl ester → L 701252 (151057-13-5)

Guidance literature:

With sodium methylate; In methanol; for 18h; Heating;

DOI:10.1021/jm00074a020

Reference yield:

2-Carboethoxy-5-chloroaniline (60064-34-8) → L 701252 (151057-13-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / Et₃N / tetrahydrofuran; toluene / -5 - 20 °C

2: 1.) LiHMDS / 1.) THF, -78-0 deg C, 30 min, 2.) THF, a.) -78 deg, 30 min, b.) -78 deg C - RT, 2 h

3: NaOMe / methanol / 18 h / Heating

With sodium methylate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; toluene;

DOI:10.1021/jm00074a020

Reference yield:

2-(ethoxycarbonyl)-5-chlorophenyl isocyanate (139422-18-7) → L 701252 (151057-13-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LiHMDS / 1.) THF, -78-0 deg C, 30 min, 2.) THF, a.) -78 deg, 30 min, b.) -78 deg C - RT, 2 h

2: NaOMe / methanol / 18 h / Heating

With sodium methylate; lithium hexamethyldisilazane; In methanol;

DOI:10.1021/jm00074a020

upstream raw materials:

2-Carboethoxy-5-chloroaniline

2-(ethoxycarbonyl)-5-chlorophenyl isocyanate

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