139422-18-7

Basic information

• Product Name: Benzoic acid, 4-chloro-2-isocyanato-, ethyl ester
• CAS NO: 139422-18-7
• Molecular Formula: C10H8ClNO3
• Molecular Weight: 225.631
• Mol File: 139422-18-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-chloro-2-isocyanato-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-chloro-2-isocyanato-, ethyl ester(139422-18-7)
• EPA Substance Registry System: Benzoic acid, 4-chloro-2-isocyanato-, ethyl ester(139422-18-7)

Safety Data

• Hazardous Substances Data: 139422-18-7(Hazardous Substances Data)

Usage

General Description

Benzoic acid, 4-chloro-2-isocyanato-, ethyl ester is a chemical compound that is commonly used as a precursor in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a building block in the production of polyurethane foams, adhesives, and coatings. Benzoic acid, 4-chloro-2-isocyanato-, ethyl ester is known for its strong odor and is often used as a fragrance in cosmetic and personal care products. Additionally, it has applications in the manufacturing of plastics and rubber products. Benzoic acid, 4-chloro-2-isocyanato-, ethyl ester should be handled and stored with care due to its potential reactivity and toxicity.

Upstream product

• 75-44-5 phosgene 
• 60064-34-8 2-Carboethoxy-5-chloroaniline 

Downstream Products

• 90181-93-4 3-benzoyl-7-chloro-4-hydroxyquinolin-2(1H)-one 
• 151057-13-5 L 701252 

Relevant articles and documents

3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically Active Anticonvulsants Acting by Antagonism at the Glycine Site of the N-Methyl-D-Aspartate Receptor Complex

Most full antagonists at the glycine site of the NMDA receptor contain a carboxylic acid, which we believe to be detrimental to penetration of the blood-brain barrier.By consideration of a pharmacophore, novel antagonists at this site have been designed in which the anionic functionality is a vinylogous acid, in the form of a 4-hydroxyquinolin-2(1H)-one.In this series, a 3-substituent is necessary for binding, and correct manipulation of this group leads to compounds such as the 3-(3-hydroxyphenyl)propargyl ester 24 (L-701,273), with an IC50 for displacement of -L-689,560 binding of 0.17 μM and Kb against NMDA in the cortical slice of 1.39 μM.Compounds were tested for their ability to prevent audiogenic seizure in DBA/2 mice; the most potent compound in this series is the cyclopropyl ketone 42 (L-701,252), with an ED50 of 4.1 mg/kg ip.A model is proposed for binding to the glycine site, in which an important interaction is of a putative receptor cation with the ?-system of the 3-substituent.