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Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
Benzoic acid, 4-chloro-2-isocyanato-, ethyl ester is used as a precursor in the synthesis of various pharmaceuticals and agrochemicals. Its unique chemical structure allows for the development of new and effective compounds for medical and agricultural applications.
Used in Polyurethane Foam Production:
As a building block, Benzoic acid, 4-chloro-2-isocyanato-, ethyl ester is used in the production of polyurethane foams. Its properties contribute to the creation of lightweight, flexible, and durable foam materials used in various industries, including furniture, bedding, and insulation.
Used in Adhesive and Coating Industries:
Benzoic acid, 4-chloro-2-isocyanato-, ethyl ester is utilized as a component in the formulation of adhesives and coatings. Its presence enhances the bonding and protective properties of these products, making them suitable for various applications, such as automotive, construction, and packaging industries.
Used in Cosmetic and Personal Care Products:
Due to its strong odor, Benzoic acid, 4-chloro-2-isocyanato-, ethyl ester is used as a fragrance in cosmetic and personal care products. It adds a pleasant scent to these products, enhancing their appeal to consumers.
Used in Plastics and Rubber Manufacturing:
Benzoic acid, 4-chloro-2-isocyanato-, ethyl ester is employed in the manufacturing of plastics and rubber products. Its incorporation into these materials contributes to their flexibility, durability, and performance in various applications, such as automotive parts, electronic components, and consumer goods.
Safety Precautions:
Due to the potential reactivity and toxicity of Benzoic acid, 4-chloro-2-isocyanato-, ethyl ester, it is crucial to handle and store the compound with care. Proper safety measures, such as wearing protective gear, working in well-ventilated areas, and following established safety protocols, should be strictly adhered to during its use and storage.

Upstream product

• 75-44-5 phosgene 
• 60064-34-8 2-Carboethoxy-5-chloroaniline 

Downstream Products

• 90181-93-4 3-benzoyl-7-chloro-4-hydroxyquinolin-2(1H)-one 
• 151057-13-5 L 701252 

Relevant academic research and scientific papers

3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically Active Anticonvulsants Acting by Antagonism at the Glycine Site of the N-Methyl-D-Aspartate Receptor Complex

Most full antagonists at the glycine site of the NMDA receptor contain a carboxylic acid, which we believe to be detrimental to penetration of the blood-brain barrier.By consideration of a pharmacophore, novel antagonists at this site have been designed in which the anionic functionality is a vinylogous acid, in the form of a 4-hydroxyquinolin-2(1H)-one.In this series, a 3-substituent is necessary for binding, and correct manipulation of this group leads to compounds such as the 3-(3-hydroxyphenyl)propargyl ester 24 (L-701,273), with an IC50 for displacement of -L-689,560 binding of 0.17 μM and Kb against NMDA in the cortical slice of 1.39 μM.Compounds were tested for their ability to prevent audiogenic seizure in DBA/2 mice; the most potent compound in this series is the cyclopropyl ketone 42 (L-701,252), with an ED50 of 4.1 mg/kg ip.A model is proposed for binding to the glycine site, in which an important interaction is of a putative receptor cation with the ?-system of the 3-substituent.

Dioxo-tetrahydroquinoline derivatives

A class of 2,4-dioxo-1,2,3,4-tetrahydroquinoline derivatives, substituted at the 3-position by a range of carbonyl-containing substituents or by a five- or six-membered heteroaromatic moiety, are selective non-competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and/or AMPA antagonist.