1,2-Pyrrolidinedicarboxylic acid, 1-(9H-fluoren-9-ylmethyl) 2-[2-[4-[2-oxo-2-(2-propenyloxy)ethoxy]phenyl]-2-(trimethylsilyl)ethyl] ester, (2S)-

Base Information

Chemical Name:1,2-Pyrrolidinedicarboxylic acid, 1-(9H-fluoren-9-ylmethyl) 2-[2-[4-[2-oxo-2-(2-propenyloxy)ethoxy]phenyl]-2-(trimethylsilyl)ethyl] ester, (2S)-
CAS No.:663191-87-5
Molecular Formula:C36H41NO7Si
Molecular Weight:627.81
Hs Code.:

1,2-Pyrrolidinedicarboxylic acid, 1-(9H-fluoren-9-ylmethyl)
2-[2-[4-[2-oxo-2-(2-propenyloxy)ethoxy]phenyl]-2-(trimethylsilyl)ethyl]
ester, (2S)-

Synonyms:

Suppliers and Price of 1,2-Pyrrolidinedicarboxylic acid, 1-(9H-fluoren-9-ylmethyl) 2-[2-[4-[2-oxo-2-(2-propenyloxy)ethoxy]phenyl]-2-(trimethylsilyl)ethyl] ester, (2S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,2-Pyrrolidinedicarboxylic acid, 1-(9H-fluoren-9-ylmethyl) 2-[2-[4-[2-oxo-2-(2-propenyloxy)ethoxy]phenyl]-2-(trimethylsilyl)ethyl] ester, (2S)-

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1,2-Pyrrolidinedicarboxylic acid, 1-(9H-fluoren-9-ylmethyl) 2-[2-[4-[2-oxo-2-(2-propenyloxy)ethoxy]phenyl]-2-(trimethylsilyl)ethyl] ester, (2S)-

There total 5 articles about 1,2-Pyrrolidinedicarboxylic acid, 1-(9H-fluoren-9-ylmethyl) 2-[2-[4-[2-oxo-2-(2-propenyloxy)ethoxy]phenyl]-2-(trimethylsilyl)ethyl] ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 71989-31-6
Fmoc-Pro-OH

: 418766-37-7
4-(2-hydroxy-1-trimethylsilylethyl)phenoxyacetic acid allyl ester

: 663191-87-5
allyl 4-[2-(N-fluorenylmethoxycarbonyl-L-prolyloxy)-1-(trimethylsilyl)-ethyl]-phenoxyacetate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1002/chem.200305304

Reference yield:

: 16722-09-1
trimethylsilyloxirane

: 663191-87-5
allyl 4-[2-(N-fluorenylmethoxycarbonyl-L-prolyloxy)-1-(trimethylsilyl)-ethyl]-phenoxyacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / diethyl ether; hexane / 2.58 h / -40 - 10 °C

1.2: CuI / diethyl ether; hexane / 1.17 h / 0 °C

1.3: 85 percent / diethyl ether; hexane / -50 - -20 °C

2.1: 90 percent / pyridinium p-toluenesulfonate / methanol / 2 h / 20 °C

3.1: 78 percent / K₂CO₃; KI / acetone / 38 h / 20 °C

4.1: 93 percent / DMAP; DCC / CH₂Cl₂ / 3 h / 0 °C

With dmap; n-butyllithium; pyridinium p-toluenesulfonate; potassium carbonate; dicyclohexyl-carbodiimide; potassium iodide; In methanol; diethyl ether; hexane; dichloromethane; acetone;
DOI:10.1002/chem.200305304

Reference yield:

: 418766-36-6
2-(4-hydroxyphenyl)-2-trimethylsilyl-ethanol

: 663191-87-5
allyl 4-[2-(N-fluorenylmethoxycarbonyl-L-prolyloxy)-1-(trimethylsilyl)-ethyl]-phenoxyacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / K₂CO₃; KI / acetone / 38 h / 20 °C

2: 93 percent / DMAP; DCC / CH₂Cl₂ / 3 h / 0 °C

With dmap; potassium carbonate; dicyclohexyl-carbodiimide; potassium iodide; In dichloromethane; acetone;
DOI:10.1002/chem.200305304