Technology Process of 2-Furancarboxaldehyde,
tetrahydro-5-methoxy-2-[(phenylmethoxy)methyl]-
There total 8 articles about 2-Furancarboxaldehyde,
tetrahydro-5-methoxy-2-[(phenylmethoxy)methyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: imidazole / CH2Cl2 / 1.42 h / 20 °C
1.2: CH2Cl2; dimethylformamide / 20 °C
2.1: 46.9 g / pyridinium chlorochromate; 4A molecular sieves / CH2Cl2 / 2 h / Heating
3.1: tetrahydrofuran / 0 - 20 °C
4.1: BH3*SMe2 / tetrahydrofuran / -78 - 20 °C
4.2: 31.7 g / pyridinium chlorochromate; 4A molecular sieves / CH2Cl2 / 48 h
5.1: diisobutylaluminum hydride / tetrahydrofuran; toluene / -78 °C
6.1: Dowex 50WX8-200; aq. AcOH / tetrahydrofuran
7.1: TBAF / tetrahydrofuran / 0 - 20 °C
8.1: 1,3-dicyclohexylcarbodiimide; dichloroacetic acid; DMSO / 16 h
With
1H-imidazole; dichloro-acetic acid; dimethylsulfide borane complex; 4 A molecular sieve; DOWEX 50WX8-200; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; acetic acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm030454h
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tetrahydrofuran / 0 - 20 °C
2.1: BH3*SMe2 / tetrahydrofuran / -78 - 20 °C
2.2: 31.7 g / pyridinium chlorochromate; 4A molecular sieves / CH2Cl2 / 48 h
3.1: diisobutylaluminum hydride / tetrahydrofuran; toluene / -78 °C
4.1: Dowex 50WX8-200; aq. AcOH / tetrahydrofuran
5.1: TBAF / tetrahydrofuran / 0 - 20 °C
6.1: 1,3-dicyclohexylcarbodiimide; dichloroacetic acid; DMSO / 16 h
With
dichloro-acetic acid; dimethylsulfide borane complex; DOWEX 50WX8-200; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; acetic acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; toluene;
DOI:10.1021/jm030454h
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 46.9 g / pyridinium chlorochromate; 4A molecular sieves / CH2Cl2 / 2 h / Heating
2.1: tetrahydrofuran / 0 - 20 °C
3.1: BH3*SMe2 / tetrahydrofuran / -78 - 20 °C
3.2: 31.7 g / pyridinium chlorochromate; 4A molecular sieves / CH2Cl2 / 48 h
4.1: diisobutylaluminum hydride / tetrahydrofuran; toluene / -78 °C
5.1: Dowex 50WX8-200; aq. AcOH / tetrahydrofuran
6.1: TBAF / tetrahydrofuran / 0 - 20 °C
7.1: 1,3-dicyclohexylcarbodiimide; dichloroacetic acid; DMSO / 16 h
With
dichloro-acetic acid; dimethylsulfide borane complex; 4 A molecular sieve; DOWEX 50WX8-200; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; acetic acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm030454h
