335393-68-5Relevant articles and documents
Diastereoselective synthesis of vicinal tertiary diols
Loertscher, Brad M.,Young, Phil R.,Evans, Patrick R.,Castle, Steven L.
supporting information, p. 1930 - 1933 (2013/06/05)
A strategy for the synthesis of differentiated vicinal tertiary diols is described. The key step is a high-yielding, diastereoselective LaCl 3·2LiCl-mediated addition of a Grignard or organolithium reagent to ketone 2a. The reaction is believed to proceed via a 1,3-chelated intermediate. One of the adducts has been transformed into a functionalized cyclopentenone resembling the core structure of pactamycin.
Conformationally Constrained Analogues of Diacylglycerol. 20. The Search for an Elusive Binding Site on Protein Kinase C through Relocation of the Carbonyl Pharmacophore Along the sn-1 Side Chain of 1,2-Diacylglycerol Lactones
Tamamura, Hirokazu,Sigano, Dina M.,Lewin, Nancy E.,Blumberg, Peter M.,Marquez, Victor E.
, p. 644 - 655 (2007/10/03)
Previous studies with 1,2-diacylglycerol (DAG) lactones, which behave as high-affinity ligands for protein kinase C (PK-C), have established the importance of maintaining intact the pharmacophore triad of two carbonyl moieties (sn-1 and sn-2) and the prim
A new synthetic route towards the mono-O-protected anti-conformationally constrained pyrimidine acyclic nucleoside.
Liu, Chi-Tsan,Tu, Tsu-Chiang,Hsu, Ling-Yih
, p. 1028 - 1030 (2007/10/03)
Novel synthetic approach to mono-O-protected anti-conformationally constrained pyrimidine acyclic nucleoside was attained from the coupling of lithiated 2,4-dimethoxy-6-methylpyrimidine with 1-benzyloxy-3-(tert-butyldiphenylsilyloxy)propan-2-one, followed by the sequential reactions of methylthiomethylation, cyclization, hydroxylation, and dealkylation.