2-[[(Ethoxycarbonyl)amino]methyl]-2-methyl Doxyl

Base Information

• Chemical Name: 2-[[(Ethoxycarbonyl)amino]methyl]-2-methyl Doxyl
• CAS No.: 663610-78-4
• Molecular Formula: C10H19N2O4
• Molecular Weight: 232.27700
• Mol file: 663610-78-4.mol

Synonyms:ethyl N-[(3-hydroxy-2,4,4-trimethyl-1,3-oxazolidin-2-yl)methyl]carbamate;

Chemical Property of 2-[[(Ethoxycarbonyl)amino]methyl]-2-methyl Doxyl

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 357.968oC at 760 mmHg
• Flash Point: 170.293oC
• PSA: 74.52000
• Density: 1.119g/cm3
• LogP: 1.09100

Purity/Quality:

98%Min ^*data from raw suppliers

2-[[(Ethoxycarbonyl)amino]methyl]-2-methylDoxyl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-[[(Ethoxycarbonyl)amino]methyl]-2-methyl Doxyl is used in the synthesis of novel DOXYL labeling reagents with electrophilic groups.

Technology Process of 2-[[(Ethoxycarbonyl)amino]methyl]-2-methyl Doxyl

There total 2 articles about 2-[[(Ethoxycarbonyl)amino]methyl]-2-methyl Doxyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-aminomethyl-3-oxyl-2,4,4-trimethyl-1,3-oxazolidine oxalic acid salt + chloroformic acid ethyl ester (541-41-3) → 2-(N-ethoxycarbonylaminomethyl)-3-oxyl-2,4,4-trimethyl-1,3-oxazolidine (663610-78-4)

Guidance literature:

With sodium hydroxide; at 0 - 20 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2003.10.089

Reference yield:

3-oxyl-2-(N-phthalimidomethyl)-2,4,4-trimethyl-1,3-oxazolidine (663610-74-0) → 2-(N-ethoxycarbonylaminomethyl)-3-oxyl-2,4,4-trimethyl-1,3-oxazolidine (663610-78-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: MeNH₂ / H₂O; diethyl ether / 0.5 h / 20 °C

1.2: H₂O

2.1: 55 percent / aq. NaOH / 0.5 h / 0 - 20 °C

With sodium hydroxide; methylamine; In diethyl ether; water;

DOI:10.1016/j.tetlet.2003.10.089

upstream raw materials:

chloroformic acid ethyl ester

3-oxyl-2-(N-phthalimidomethyl)-2,4,4-trimethyl-1,3-oxazolidine