8-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)-3,4-dihydro-1-oxo-1H-2-benzopyran-4-carboxylic acid

Base Information

Chemical Name:8-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)-3,4-dihydro-1-oxo-1H-2-benzopyran-4-carboxylic acid
CAS No.:66380-90-3
Molecular Formula:C17H14O7
Molecular Weight:330.28900
Hs Code.:

Synonyms:8-Hydroxy-3-(3-hydroxy-4-methoxy-phenyl)-1-oxo-isochroman-7-carboxylic acid;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)-3,4-dihydro-1-oxo-1H-2-benzopyran-4-carboxylic acid

Chemical Property:

Boiling Point:615.7±55.0 °C(Predicted)
PKA:2.58±0.40(Predicted)
PSA：113.29000
Density:1.491±0.06 g/cm3(Predicted)
LogP:2.25880

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 8-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)-3,4-dihydro-1-oxo-1H-2-benzopyran-4-carboxylic acid

There total 6 articles about 8-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)-3,4-dihydro-1-oxo-1H-2-benzopyran-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 66380-93-6
2-hydroxy-4-<2-(3-hydroxy-4-methoxyphenyl)ethenyl>-1,3-benzenedicarboxylic acid

: 66380-90-3
3,4-dihydro-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-7-isocoumarincarboxylic acid

Guidance literature:: With sulfuric acid; at 0 ℃; for 0.5h;

Reference yield:

: 66380-88-9
dimethyl 4-<2-(3-benzyloxy-4-methoxyphenyl)ethenyl>-2-hydroxy-1,3-benzenedicarboxylate

: 66380-90-3
3,4-dihydro-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-7-isocoumarincarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / conc. HCl / methanol

2: 98 percent / 10percent KOH / methanol; H₂O

3: 72 percent / conc. H₂SO₄ / 0.17 h / 0 °C

With hydrogenchloride; potassium hydroxide; sulfuric acid; In methanol; water;
DOI:10.1039/c39800000593

Reference yield:

: 66380-91-4
(E)-4-(3-(benzyloxy)-4-methoxyphenyl) but-3-en-2-one

: 66380-90-3
3,4-dihydro-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-7-isocoumarincarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / dimethylformamide

2: 47.4 percent / AcOH, AcONa, 18-crown-6 / benzene / 12 h / 70 °C

3: 68 percent / conc. HCl / methanol

4: 98 percent / 10percent KOH / methanol; H₂O

5: 72 percent / conc. H₂SO₄ / 0.17 h / 0 °C

With hydrogenchloride; potassium hydroxide; 18-crown-6 ether; sulfuric acid; sodium acetate; acetic acid; In methanol; water; N,N-dimethyl-formamide; benzene;
DOI:10.1039/c39800000593