66380-91-4

Upstream product

• 67-64-1 acetone 
• 6346-05-0 3-benzyloxy-4-methoxybenzaldehyde 

Downstream Products

• 66380-92-5 1-(3-benzyloxy-4-methoxyphenyl)-5-dimethylamino-1,4-pentadien-3-one 
• 1396341-86-8 (E)-1-(benzo[d]thiazol-2-yl)-3-(3-(benzyloxy)-4-methoxyphenyl)prop-2-en-1-one 
• 66380-87-8 (+/-)-3-(3-benzyloxy-4-methoxyphenyl)-3,4-dihydro-8-hydroxy-1H-2-benzopyran-1-one 
• 66380-86-7 3-(3-benzyloxy-4-methoxyphenyl)-3,4-dihydro-8-hydroxy-7-isocumarincarboxylic acid 
• 66380-85-6 4-<2-(3-benzyloxy-4-methoxyphenyl)ethenyl>-2-hydroxy-1,3-benzenedicarboxylic acid 
• 55555-33-4 phyllodulcin 
• 66380-89-0 dimethyl 2-hydroxy-4-<2-(3-hydroxy-4-methoxyphenyl)ethenyl>-1,3-benzenedicarboxylate 
• 66380-90-3 3,4-dihydro-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-7-isocoumarincarboxylic acid 
• 66380-93-6 2-hydroxy-4-<2-(3-hydroxy-4-methoxyphenyl)ethenyl>-1,3-benzenedicarboxylic acid 
• 66380-88-9 dimethyl 4-<2-(3-benzyloxy-4-methoxyphenyl)ethenyl>-2-hydroxy-1,3-benzenedicarboxylate 

Relevant academic research and scientific papers

An Easy Two Synthon Synthesis of a Sweet Dihydroisocoumarin, (+/-)-Phyllodulcin

A short synthesis of (+/-)-phyllodulcin (1), a sweet principle of Hydrangea serrata Seringe var. thunbergii Sugimoto, from the enaminone (2) by annelation with dimethyl 3-oxaglutarate is decribed.

An Easy Two-Synthon Synthesis of a Sweet Dihydroisocoumarin, (+/-)-Phyllodulcin. Studies on the β-carbonyl Compounds Connected with β-Polyketides. IX

(+/-)-Phyllodulcin (1), a sweet dihydroisocoumarin of Hydrangea serrata SERINGE var. thunbergii SUGIMOTO, was synthesized by aromatic annelation of two synthons 2 and 3 to yield 5, followed by successive debenzylation, hydrolysis, lactonization, and decar