4-(Benzyloxy)-3-chlorobenzaldehyde

Base Information

• Chemical Name: 4-(Benzyloxy)-3-chlorobenzaldehyde
• CAS No.: 66422-84-2
• Molecular Formula: C14H11ClO2
• Molecular Weight: 246.693
• Hs Code.: 2913000090
• DSSTox Substance ID: DTXSID90370749
• Nikkaji Number: J952.273E
• Wikidata: Q82157901
• Mol file: 66422-84-2.mol

Synonyms:4-(Benzyloxy)-3-chlorobenzaldehyde;66422-84-2;Benzaldehyde, 3-chloro-4-(phenylmethoxy)-;3-chloro-4-phenylmethoxybenzaldehyde;4-Benzyloxy-3-chlorobenzaldehyde;4-Benzyloxy-3-chloro-benzaldehyde;Arachidonicacidanhydride;SCHEMBL1050683;DTXSID90370749;XFPGRCKILOWFOL-UHFFFAOYSA-N;3-Chloro-4-(benzyloxy)benzaldehyde;BBL023590;MFCD00831645;STK198920;AKOS000295170;PS-7519;NCGC00341008-01;3-chloro-4-[(phenylmethyl)oxy]benzaldehyde;BB 0241778;CS-0186882;FT-0616694;D87662;AB01331855-02;A835460

Chemical Property of 4-(Benzyloxy)-3-chlorobenzaldehyde

Chemical Property:

• Vapor Pressure: 2.92E-06mmHg at 25°C
• Melting Point: 89-91oC
• Boiling Point: 389.1oC at 760 mmHg
• Flash Point: 162.2oC
• PSA: 26.30000
• Density: 1.247g/cm3
• LogP: 3.73150
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 246.0447573
• Heavy Atom Count: 17
• Complexity: 238

Purity/Quality:

98%min ^*data from raw suppliers

4-(Benzyloxy)-3-chlorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=C(C=C(C=C2)C=O)Cl

Technology Process of 4-(Benzyloxy)-3-chlorobenzaldehyde

There total 13 articles about 4-(Benzyloxy)-3-chlorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-hydroxy-3-chlorobenzaldehyde (2420-16-8) + benzyl bromide (100-39-0) → 4-benzyloxy-3-chlorobenzaldehyde (66422-84-2)

Guidance literature:

With potassium carbonate;

DOI:10.1016/S0957-4166(97)00603-4

Reference yield: 83.0%

(4-benzyloxy-3-chlorophenyl)methanol (536974-87-5) → 4-benzyloxy-3-chlorobenzaldehyde (66422-84-2)

Guidance literature:

With dipyridinium dichromate; Mol_.s.4A; In dichloromethane;

DOI:10.1016/S0040-4039(98)00172-5

Reference yield: 35.0%

4-hydroxy-3-chlorobenzaldehyde (2420-16-8) + 1-bromomethyl-2-chlorobenzene (611-17-6) → 4-benzyloxy-3-chlorobenzaldehyde (66422-84-2)

Guidance literature:

With potassium carbonate; In acetonitrile; Reflux; Inert atmosphere;

upstream raw materials:

4-hydroxy-3-chlorobenzaldehyde

benzyl chloride

benzyl bromide

(4-benzyloxy-3-chlorophenyl)methanol

Downstream raw materials:

(E)-3-[4-(benzyloxy)-3-chlorophenyl]-1-(2-hydroxy-5-methyl-3-nitrophenyl)-2-propen-1-one

5-(4-(benzyloxy)-3-chlorobenzylidene)thiazolidine-2,4-dione

2-(4-(benzyloxy)-3-chlorophenyl)acetonitrile

C₃₁H₃₁ClN₂O₄