2-(Furan-2-yl)imidazo[1,2-a]pyrimidine

Base Information

• Chemical Name: 2-(Furan-2-yl)imidazo[1,2-a]pyrimidine
• CAS No.: 66442-83-9
• Molecular Formula: C₁₀H₇N₃O
• Molecular Weight: 185.185
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID80496821
• Nikkaji Number: J2.196.754H

Synonyms:2-(Furan-2-yl)imidazo[1,2-a]pyrimidine;66442-83-9;2-Furan-2-yl-imidazo[1,2-a]pyrimidine;MFCD07371404;2-(2-Furyl)imidazo[1,2-a]pyrimidine;DTXSID80496821;AKOS005257132;MS-20175

Chemical Property of 2-(Furan-2-yl)imidazo[1,2-a]pyrimidine

Chemical Property:

• PSA: 43.33000
• Density: 1.375g/cm3
• LogP: 1.98930
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 185.058911855
• Heavy Atom Count: 14
• Complexity: 212

Purity/Quality:

97% ^*data from raw suppliers

2-Furan-2-yl-imidazo[1,2-a]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN2C=C(N=C2N=C1)C3=CC=CO3

Technology Process of 2-(Furan-2-yl)imidazo[1,2-a]pyrimidine

There total 5 articles about 2-(Furan-2-yl)imidazo[1,2-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-aminopyrimidine (109-12-6) + 1-(2-furyl)-1-ethanone (1192-62-7,80145-44-4) → (furyl-2)-2 imidazo<1,2-a>pyrimidine (66442-83-9)

Guidance literature:

1-(2-furyl)-1-ethanone; With [hydroxy(tosyloxy)iodo]benzene; N-butylpyridinium tetrafluoroborate; Heating;

2-aminopyrimidine; With sodium carbonate; N-butylpyridinium tetrafluoroborate; at 20 ℃;

DOI:10.1081/SCC-200063911

Reference yield: 58.0%

2-amino-1-(2-furoylmethyl)pyrimidinium bromide → (furyl-2)-2 imidazo<1,2-a>pyrimidine (66442-83-9)

Guidance literature:

With sodium hydrogencarbonate; for 3h; Heating;

DOI:10.1007/s10593-006-0116-0

Reference yield: 32.0%

2-aminopyrimidine (109-12-6) + 1-(2-furyl)-2-bromoethanone (15109-94-1) → (furyl-2)-2 imidazo<1,2-a>pyrimidine (66442-83-9)

Guidance literature:

In acetonitrile; 1.) room temp., 1 h, 2.) reflux, 24 h;

DOI:10.1016/0223-5234(87)90036-5

upstream raw materials:

2-aminopyrimidine

1-(2-furyl)-2-bromoethanone

1-(2-furyl)-1-ethanone

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