1,4-difluoro-2-methoxy-5-nitrobenzene

Base Information

• Chemical Name: 1,4-difluoro-2-methoxy-5-nitrobenzene
• CAS No.: 66684-63-7
• Molecular Formula: C7H5F2NO3
• Molecular Weight: 189.118
• Mol file: 66684-63-7.mol

Synonyms:Benzene,1,4-difluoro-2-methoxy-5-nitro;2,5-Difluor-4-methoxynitrobenzol;1,4-difluoro-2-methoxy-5-nitro-benzene;

Chemical Property of 1,4-difluoro-2-methoxy-5-nitrobenzene

Chemical Property:

• PSA: 55.05000
• LogP: 2.40480

Purity/Quality:

1,4-difluoro-2-methoxy-5-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-difluoro-2-methoxy-5-nitrobenzene

There total 2 articles about 1,4-difluoro-2-methoxy-5-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2.5-difluoro-4-nitrophenol (120103-18-6) + methyl iodide (74-88-4) → 1,4-difluoro-2-methoxy-5-nitro-benzene (66684-63-7)

Guidance literature:

2.5-difluoro-4-nitrophenol; With 18-crown-6 ether; potassium carbonate; In butanone; at 20 ℃; for 0.5h;

methyl iodide; In butanone; at 40 ℃; for 168h;

Reference yield:

1,2,4-trifluoro-5-nitrobenzene (2105-61-5) → 1,5-Difluoro-4-methoxy-phenylamine + 1,4-difluoro-2-methoxy-5-nitro-benzene (66684-63-7)

Guidance literature:

With sodium methylate; In methanol;

Reference yield: 98.0%

trans-4-aminomethyl-cyclohexanecarboxylic acid methyl ester + 1,4-difluoro-2-methoxy-5-nitro-benzene (66684-63-7) → trans-4-[(4-fluoro-5-methoxy-2-nitro-phenylamino)-methyl]-cyclohexane carboxylic acid methyl ester

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 3h;

upstream raw materials:

1,2,4-trifluoro-5-nitrobenzene

2.5-difluoro-4-nitrophenol

methyl iodide

Refernces

• 1、 -. "WNT PATHWAY ANTAGONISTS". Page/Page column 51-52. . Retrieved 2012/10/18.