Morpholine, 2-[(S)-bromophenylmethyl]-4-(phenylmethyl)-, (2R)-

Base Information

Chemical Name:Morpholine, 2-[(S)-bromophenylmethyl]-4-(phenylmethyl)-, (2R)-
CAS No.:667876-78-0
Molecular Formula:C18H20BrNO
Molecular Weight:346.267
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Morpholine, 2-[(S)-bromophenylmethyl]-4-(phenylmethyl)-, (2R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
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MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Morpholine, 2-[(S)-bromophenylmethyl]-4-(phenylmethyl)-, (2R)-

There total 5 articles about Morpholine, 2-[(S)-bromophenylmethyl]-4-(phenylmethyl)-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (SR)-phenyl[(2SR)-4-(phenylmethyl)morpholin-2-yl]methanol

: 667876-79-1
(2S,3R)-4-benzyl-2-(bromophenylmethyl)morpholine

: 667876-78-0
(2R,3S)-4-benzyl-2-(bromophenylmethyl)morpholine

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃; for 0.25h;

Reference yield:

: 667876-82-6
(2R,3R)-(4-benzylmorpholin-2-yl)phenylmethanol

: 668470-83-5
(2S,3S)-(4-benzylmorpholin-2-yl)phenylmethanol

: 667876-79-1
(2S,3R)-4-benzyl-2-(bromophenylmethyl)morpholine

: 667876-78-0
(2R,3S)-4-benzyl-2-(bromophenylmethyl)morpholine

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃; for 0.25h;

Reference yield:

: 98-88-4
benzoyl chloride

: 667876-78-0
(2R,3S)-4-benzyl-2-(bromophenylmethyl)morpholine

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

2.2: -78 - 10 °C

3.1: acetic acid; triethylamine; [N-[(1R,2R)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2, 3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]-ruthenium / dichloromethane / 24 h / 35 °C

4.1: borane-THF / tetrahydrofuran / 3 h / 60 °C / Inert atmosphere

5.1: triphenylphosphine dibromide 1:1 addition complex / dichloromethane / 6 h / 50 °C / Inert atmosphere; Reflux

With borane-THF; [N-[(1R,2R)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2, 3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]-ruthenium; acetic acid; triphenylphosphine dibromide 1:1 addition complex; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo401102d