Technology Process of L-Leucine, N,N'-[1,4-phenylenebis(1-oxo-2,1-ethanediyl)]bis-, dimethyl
ester
There total 3 articles about L-Leucine, N,N'-[1,4-phenylenebis(1-oxo-2,1-ethanediyl)]bis-, dimethyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1,4-phenylenediacetic acid;
With
dicyclohexyl-carbodiimide;
In
dichloromethane;
for 3h;
methyl (L)-leucinate hydrochloride;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 0 - 20 ℃;
DOI:10.1007/s00706-003-0029-x
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 90 percent / conc. HCl; acetic acid / 2 h / 100 °C
2.1: N,N'-dicyclohexylcarbodiimide / CH2Cl2 / 3 h
2.2: 34 percent / diisopropylethylamine / CH2Cl2 / 0 - 20 °C
With
hydrogenchloride; acetic acid; dicyclohexyl-carbodiimide;
In
dichloromethane;
DOI:10.1007/s00706-003-0029-x
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 87 percent / triethylene glycol / 1 h / 90 °C
2.1: 90 percent / conc. HCl; acetic acid / 2 h / 100 °C
3.1: N,N'-dicyclohexylcarbodiimide / CH2Cl2 / 3 h
3.2: 34 percent / diisopropylethylamine / CH2Cl2 / 0 - 20 °C
With
hydrogenchloride; acetic acid; dicyclohexyl-carbodiimide;
In
dichloromethane; 2,2'-[1,2-ethanediylbis(oxy)]bisethanol;
DOI:10.1007/s00706-003-0029-x
