Madhp

Base Information

Chemical Name:Madhp
CAS No.:97142-19-3
Molecular Formula:C₂₅H₃₄O₆
Molecular Weight:430.541
Hs Code.:
DSSTox Substance ID:DTXSID50914108
Mol file:97142-19-3.mol

Synonyms:MADHP;methyl 17,20-acetonidodihydroprednisolonate

Suppliers and Price of Madhp

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Madhp

Chemical Property:

Boiling Point:547.6°Cat760mmHg
Flash Point:181°C
PSA：82.06000
Density:1.24g/cm³
LogP:3.32840
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:430.23553880
Heavy Atom Count:31
Complexity:888

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(OC(C2(O1)CCC3C2(CC(C4C3CCC5=CC(=O)C=CC45C)O)C)C(=O)OC)C
Isomeric SMILES:C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CCC24[C@@H](OC(O4)(C)C)C(=O)OC)CCC5=CC(=O)C=C[C@]35C)O

Technology Process of Madhp

There total 3 articles about Madhp which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 97232-42-3
methyl 11β,17α,20α-trihydroxy-3-oxo-1,4-pregnadiene-21-oate

: 77-76-9
2,2-dimethoxy-propane

: 97142-19-3
methyl 17,20α-acetonidodihydroprednisolonate

Guidance literature:: With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 43 ℃; for 48h;
DOI:10.1016/S0039-128X(01)00189-1

Reference yield:

: 50-24-8,8056-11-9
prednisolon

: 97142-19-3
methyl 17,20α-acetonidodihydroprednisolonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: cupric acetate monohydrate / methanol / 48 h

1.2: NaOH / H₂O / 1 h

2.1: 51 percent / ethyl acetate; diethyl ether

3.1: 54 percent / p-toluenesulfonic acid monohydrate / dimethylformamide / 48 h / 43 °C

With copper diacetate; toluene-4-sulfonic acid; In methanol; diethyl ether; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0039-128X(01)00189-1

Reference yield:

: 62358-12-7
11β,17α,20α-trihydroxy-3-oxo-1,4-pregnadien-21-oic acid

: 97142-19-3
methyl 17,20α-acetonidodihydroprednisolonate

Guidance literature:: Multi-step reaction with 2 steps

1: 51 percent / ethyl acetate; diethyl ether

2: 54 percent / p-toluenesulfonic acid monohydrate / dimethylformamide / 48 h / 43 °C

With toluene-4-sulfonic acid; In diethyl ether; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0039-128X(01)00189-1