2,2-Dimethoxypropane

Base Information

• Chemical Name: 2,2-Dimethoxypropane
• CAS No.: 77-76-9
• Molecular Formula: C5H12O2
• Molecular Weight: 104.149
• Hs Code.: 29110000
• European Community (EC) Number: 201-056-0
• NSC Number: 62085
• UNII: 66P41R0030
• DSSTox Substance ID: DTXSID7026441
• Nikkaji Number: J35.930K
• Wikipedia: 2,2-Dimethoxypropane
• Wikidata: Q4596749
• ChEMBL ID: CHEMBL3184215
• Mol file: 77-76-9.mol

Synonyms:2,2-dimethoxypropane

Chemical Property of 2,2-Dimethoxypropane

Chemical Property:

• Appearance/Colour: clear liquid
• Vapor Pressure: 60 mm Hg ( 15.8 °C)
• Melting Point: -47 °C
• Refractive Index: n20/D 1.378(lit.)
• Boiling Point: 83 °C at 760 mmHg
• Flash Point: -5oC
• PSA: 18.46000
• Density: 0.84 g/cm³
• LogP: 1.01530
• Storage Temp.: Flammables area
• Solubility.: 180g/l
• Water Solubility.: 18 g/100 mL (25 ºC)
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 104.083729621
• Heavy Atom Count: 7
• Complexity: 44

Purity/Quality:

99% ^*data from raw suppliers

2,2-Dimethoxypropane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,Xi
• Hazard Codes: F,Xi
• Statements: 11-36-36/37/38
• Safety Statements: 26-9-37/39-33-16-33,37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Acetals
• Canonical SMILES: CC(C)(OC)OC
• Uses: 2,2-Dimethoxypropane(DMP) is used in histology and considered to be more efficient than ethanol for the dehydration of animal tissue. 2,2-Dimethoxypropane acts as a dehydrating agent. It also serves as an intermediate in the synthesis of vitamin E, vitamin A and various carotenoids such as astaxanthin. It is used as a reagent for the preparation of 1,2-diols, acetonides, isopropylidene derivatives of sugars, nucleosides, methyl esters of amino acids and enol ethers.

Technology Process of 2,2-Dimethoxypropane

There total 45 articles about 2,2-Dimethoxypropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

acetone (67-64-1) → 2,2-dimethoxy-propane (77-76-9)

Guidance literature:

With dihydrogen peroxide; In water; acetonitrile; at 20 ℃; for 0.25h; Green chemistry;

DOI:10.3184/174751916X14792244600532

Reference yield: 92.0%

pyridoxal hydrochloride (58-56-0) → 1,5-dihydro-3,3,8-trimethyl<1,3>dioxepino<5,6-y>pyridin-9-ol (948-00-5) + 2,2-dimethoxy-propane (77-76-9)

Guidance literature:

With sulfuric acid; In dichloromethane; for 6h; Title compound not separated from byproducts; Heating;

DOI:10.3891/acta.chem.scand.43-1009

Reference yield: 91.0%

2,2,4-trimethyl-1,3-dioxolane (1193-11-9,116944-25-3) + methanol (67-56-1) → 2,2-dimethoxy-propane (77-76-9)

Guidance literature:

With aluminum (III) chloride; at 70 ℃; for 5.6h; Temperature;

upstream raw materials:

methanol

Isopropenyl acetate

1,2-propanediene

tetramethylorthosilicate

Downstream raw materials:

((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

2-Methoxypropene

3-((3aS,4S,6aR)-6-Benzoyloxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-isoxazole-5-carboxylic acid ethyl ester

methyl 2,2-dimethoxypropionate

Refernces

• 1、 He, Jianghua,He, Lin,Li, Zhen,Liu, Jianhua,Liu, Mengli,Wang, Fang,Xia, Chungu,Yun, Dong,Zeng, Bo. "On the origin of nitrogen-containing promoters in the cobalt-catalyzed methoxycarbonylation of epoxides". . . Retrieved 2021/07/26.
• 2、 -. "Method for preparing 2,2-dimethoxy propane". Paragraph 0032; 0034; 0035; 0036; 0037; 0039-0041. . Retrieved 2019/04/02.