Pyridine, 1,2,3,6-tetrahydro-4-[4-(trifluoromethyl)phenyl]-

Base Information

• Chemical Name: Pyridine, 1,2,3,6-tetrahydro-4-[4-(trifluoromethyl)phenyl]-
• CAS No.: 67259-64-7
• Molecular Formula: C12H12F3N
• Molecular Weight: 227.229
• DSSTox Substance ID: DTXSID901199942

Synonyms:67259-64-7;Pyridine, 1,2,3,6-tetrahydro-4-[4-(trifluoromethyl)phenyl]-;4-(4-(Trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine;4-[4-(TRIFLUOROMETHYL)PHENYL]-1,2,3,6-TETRAHYDROPYRIDINE;starbld0019632;SCHEMBL1472528;DTXSID901199942;AKOS000205070;CS-0304057;EN300-125322;4-(4-Trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine;1,2,3,6-Tetrahydro-4-[4-(trifluoromethyl)phenyl]pyridine;4-(4-Trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyridine;1,2,3,6-tetrahydro-4-(alpha,alpha,alpha-trifluoro-p-tolyl)pyridine

Chemical Property of Pyridine, 1,2,3,6-tetrahydro-4-[4-(trifluoromethyl)phenyl]-

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 227.09218387
• Heavy Atom Count: 16
• Complexity: 262

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCC=C1C2=CC=C(C=C2)C(F)(F)F

Technology Process of Pyridine, 1,2,3,6-tetrahydro-4-[4-(trifluoromethyl)phenyl]-

There total 7 articles about Pyridine, 1,2,3,6-tetrahydro-4-[4-(trifluoromethyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(4-trifluoromethyl-phenyl)-pyridine (220000-88-4) → 1,2,3,6-tetrahydro-4-(α,α,α-trifluoro-p-tolyl)pyridine (67259-64-7)

Guidance literature:

With triphenylborane; diphenylsilane; diphenylamine; In toluene; at 120 ℃; for 24h; chemoselective reaction; Glovebox; Inert atmosphere;

DOI:10.1002/anie.201702304

Reference yield: 90.0%

4-methyl-4-[4-(trifluoromethyl)phenyl]piperidine → 1,2,3,6-tetrahydro-4-(α,α,α-trifluoro-p-tolyl)pyridine (67259-64-7)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 12h; Heating / reflux;

Reference yield:

1-t-Butoxycarbonyl-4-(4-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine (437998-30-6) → 1,2,3,6-tetrahydro-4-(α,α,α-trifluoro-p-tolyl)pyridine (67259-64-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 40 ℃; for 3h;

upstream raw materials:

1-t-Butoxycarbonyl-4-(4-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine

4-(4-trifluoromethyl-phenyl)-pyridine

p-trifluoromethylphenyl bromide

4-trifluoromethylphenylboronic acid

Downstream raw materials:

2-{4-[4-(4-trifluoromethyl-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-butyrylamino}-benzamide

4-(4-(trifluoromethyl)phenyl)piperidine

7-(2-(4-(4-Trifluoromethylphenyl)-1,2,3,6-tetrahydropyrid-1-yl)ethyl)isoquinoline

{2-methyl-5-[4-(4-trifluoromethyl-phenyl)-3,6-dihydro-2H-pyridine-1-sulfonyl]-phenyl}-acetic acid ethyl ester

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