220000-88-4

Basic information

• Product Name: 4-(4-TRIFLUOROMETHYLPHENYL)PYRIDINE
• Synonyms: 4-(4-TRIFLUOROMETHYLPHENYL)PYRIDINE
• CAS NO: 220000-88-4
• Molecular Formula: C₁₂H₈F₃N
• Molecular Weight: 223.19
• Mol File: 220000-88-4.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 263.3 °C at 760 mmHg
• Flash Point: 113 °C
• Appearance: /
• Density: 1.23 g/cm³
• Vapor Pressure: 0.0169mmHg at 25°C
• Refractive Index: 1.506
• Storage Temp.: 2-8°C(protect from light)
• PKA: 4.89±0.10(Predicted)
• CAS DataBase Reference: 4-(4-TRIFLUOROMETHYLPHENYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-TRIFLUOROMETHYLPHENYL)PYRIDINE(220000-88-4)
• EPA Substance Registry System: 4-(4-TRIFLUOROMETHYLPHENYL)PYRIDINE(220000-88-4)

Safety Data

• Hazardous Substances Data: 220000-88-4(Hazardous Substances Data)

Usage

General Description

4-(4-Trifluoromethylphenyl)pyridine is an organic compound with the chemical formula C12H8F3N. It is a pyridine derivative, which is a heterocyclic aromatic compound containing a six-membered ring with five carbon atoms and one nitrogen atom. The molecule consists of a pyridine ring substituted with a 4-(4-trifluoromethylphenyl) group, which imparts the compound with its unique chemical and physical properties. 4-(4-TRIFLUOROMETHYLPHENYL)PYRIDINE is used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It also has potential applications in materials science and chemical research due to its structural and electronic properties. 4-(4-Trifluoromethylphenyl)pyridine is a versatile compound with diverse potential uses in the field of chemistry.

InChI:InChI=1/C12H8F3N/c13-12(14,15)11-3-1-9(2-4-11)10-5-7-16-8-6-10/h1-8H

Upstream product

• 455-13-0 4-Iodobenzotrifluoride 
• 113964-72-0 triphenyl(pyridin-4-yl)phosphonium trifluoromethanesulfonate 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 116008-37-8 sodium pyridine-4-sulfinate 
• 110-86-1 pyridine 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 455-24-3 4-trifluoromethylbenzoic acid 
• 55-22-1 pyridine-4-carboxylic acid 
• 1692-15-5 4-pyridylboronic acid 
• 30459-17-7 1-[4-(trifluoromethyl)phenyl]piperazine 
• 110-71-4 1,2-dimethoxyethane 
• 626-61-9 4-Chloropyridine 

Downstream Products

• 1012886-69-9 C₁₃H₁₁F₃N⁽¹⁺⁾*I^(1-) 
• 67259-63-6 4-(4-(trifluoromethyl)phenyl)piperidine 
• 1268865-74-2 methyl 3-(4-fluorophenyl)-2-(4-(4-(trifluoromethyl)phenyl)piperidin-1-yl)quinoxaline-6-carboxylate 
• 1268862-81-2 3-(4-fluorophenyl)-2-(4-(4-(trifluoromethyl)phenyl)piperidin-1-yl)quinoxaline-6-carboxylic acid 
• 1268865-26-4 methyl 2-phenyl-3-(4-(4-(trifluoromethyl)phenyl)piperidin-1-yl)quinoxaline-6-carboxylate 
• 1268862-36-7 2-phenyl-3-(4-(4-(trifluoromethyl)phenyl)piperidin-1-yl)quinoxaline-6-carboxylic acid 
• 67259-64-7 1,2,3,6-tetrahydro-4-(α,α,α-trifluoro-p-tolyl)pyridine 
• 545396-52-9 4-(4-trifluoromethyl-phenyl)-pyridine 1-oxide 

Relevant articles and documents

Organocatalytic synthesis of (Het)biaryl scaffoldsviaphotoinduced intra/intermolecular C(sp2)-H arylation by 2-pyridone derivatives

A uniqueN,O-bidentate ligand 6-oxo-1,6-dihydro-pyridone-2-carboxylic acid dimethylamide (L1) catalyzed direct C(sp2)-H (intra/intermolecular) arylation of unactivated arenes has been developed to expedite access to (Het)biaryl scaffolds under UV-irradiation at room temperature. The protocol tolerated diverse functional groups and substitution patterns, affording the target products in moderate to excellent yields. Mechanistic investigations were also carried out to better understand the reaction pathway. Furthermore, the synthetic applicability of this unified approach has been showcasedviathe construction of biologically relevant 4-quinolone, tricyclic lactam and sultam derivatives.

Palladium-Catalyzed Electrophilic Functionalization of Pyridine Derivatives through Phosphonium Salts

Herein, we report a highly efficient and practical method for pyridine-derived heterobiaryl synthesis through palladium-catalyzed electrophilic functionalization of easily available pyridine-derived quaternary phosphonium salts. The nice generality of this reaction was goes beyond arylation, enabling facile incorporation of diverse carbon-based fragments, including alkenyl, alkynyl, and also allyl fragments, onto the pyridine core. Notably, the silver salt additive is revealed to be of vital importance for the success of this transformation and its pivotal role as transmetallation mediator, which guarantees a smooth transfer of pyridyl group to palladium intermediate, is also described.

Phosphonium Salts as Pseudohalides: Regioselective Nickel-Catalyzed Cross-Coupling of Complex Pyridines and Diazines

Heterobiaryls are important pharmacophores that are challenging to prepare by traditional cross-coupling methods. An alternative approach is presented where pyridines and diazines are converted into heteroaryl phosphonium salts and coupled with aryl boronic acids. Nickel catalysts are unique for selective heteroaryl transfer, and the reaction has a broad substrate scope that includes complex pharmaceuticals. Phosphonium ions also display orthogonal reactivity in cross-couplings compared to halides, enabling chemoselective palladium- and nickel-catalyzed coupling sequences.