(1R,2S)-1-Chloro-2-(methoxymethyl)cyclohexane

Base Information

• Chemical Name: (1R,2S)-1-Chloro-2-(methoxymethyl)cyclohexane
• CAS No.: 67295-03-8
• Molecular Formula: C₈H₁₅ClO
• Molecular Weight: 162.66
• DSSTox Substance ID: DTXSID70498793
• Wikidata: Q82349079
• Mol file: 67295-03-8.mol

Synonyms:(1R,2S)-1-Chloro-2-(methoxymethyl)cyclohexane;67295-03-8;DTXSID70498793;trans-1-methoxymethyl-2-chlorocyclohexane

Chemical Property of (1R,2S)-1-Chloro-2-(methoxymethyl)cyclohexane

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 162.0811428
• Heavy Atom Count: 10
• Complexity: 95.3

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC1CCCCC1Cl
• Isomeric SMILES: COC[C@@H]1CCCC[C@H]1Cl

Technology Process of (1R,2S)-1-Chloro-2-(methoxymethyl)cyclohexane

There total 1 articles about (1R,2S)-1-Chloro-2-(methoxymethyl)cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloromethyl methyl ether (107-30-2) + cyclohexene (110-83-8) → trans-1-methoxymethyl-2-chlorocyclohexane (18964-35-7,67295-03-8,138043-23-9)

Guidance literature:

With zinc(II) chloride;

Reference yield:

trans-1-methoxymethyl-2-chlorocyclohexane (18964-35-7,67295-03-8,138043-23-9) → cis-3-phenyl-trans-2-oxadecalin (138043-12-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) Mg, MeI / 1.) ether, reflux, 1 h, 2.) ether, -5 deg C

2: TsCl, pyridine / 1 h / 100 °C

3: 1.) Mg, MeI / 1.) ether, reflux, 1 h, 2.) ether, -15 deg C

4: TsCl, pyridine / 1.5 h / 100 °C

With pyridine; magnesium; p-toluenesulfonyl chloride; methyl iodide;

DOI:10.1007/BF01172270

Reference yield:

trans-1-methoxymethyl-2-chlorocyclohexane (18964-35-7,67295-03-8,138043-23-9) → trans-1-methoxymethyl-2-chloromethylcyclohexane (137303-15-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Mg, MeI / 1.) ether, reflux, 1 h, 2.) ether, -5 deg C

2: TsCl, pyridine / 1 h / 100 °C

With pyridine; magnesium; p-toluenesulfonyl chloride; methyl iodide;

DOI:10.1007/BF01172270

upstream raw materials:

chloromethyl methyl ether

cyclohexene

Downstream raw materials:

trans-1-methoxymethyl-2-hydroxymethylcyclohexane

trans-1-methoxymethyl-2-(1-hydroxyethyl)cyclohexane

trans-1-methoxymethyl-2-(1-hydroxybutyl)cyclohexane

trans-1-methoxymethyl-2-chloromethylcyclohexane