4-(3-Fluoro-4-hydroxyphenyl)butyric acid

Base Information

• Chemical Name: 4-(3-Fluoro-4-hydroxyphenyl)butyric acid
• CAS No.: 588-25-0
• Molecular Formula: C10H11FO3
• Molecular Weight: 198.194
• European Community (EC) Number: 209-614-5
• DSSTox Substance ID: DTXSID30207525
• Nikkaji Number: J188.455G
• Wikidata: Q83081438
• Mol file: 588-25-0.mol

Synonyms:4-(3-fluoro-4-hydroxyphenyl)butanoic acid;588-25-0;4-(3-Fluoro-4-hydroxyphenyl)butyric acid;EINECS 209-614-5;SCHEMBL7813938;DTXSID30207525;AKOS006274172;3-Fluoro-4-hydroxybenzenebutanoic acid;4-(3-fluoro-4-hydroxyphenyl)butanoicacid;CS-0236723;EN300-172441

Chemical Property of 4-(3-Fluoro-4-hydroxyphenyl)butyric acid

Chemical Property:

• Vapor Pressure: 2.69E-05mmHg at 25°C
• Boiling Point: 343.4°Cat760mmHg
• Flash Point: 161.5°C
• Density: 1.299g/cm³
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 198.06922237
• Heavy Atom Count: 14
• Complexity: 196

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1CCCC(=O)O)F)O

Technology Process of 4-(3-Fluoro-4-hydroxyphenyl)butyric acid

There total 2 articles about 4-(3-Fluoro-4-hydroxyphenyl)butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

γ-(3-fluoro-4-methoxy)-γ-oxobenzenebutanoic acid (347-63-7) → 4-(3-fluoro-4-hydroxy-phenyl)-butyric acid (588-25-0)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; diethylene glycol;

DOI:10.1021/jo01353a028

Reference yield:

1-fluoro-2-methoxybenzene (321-28-8) → 4-(3-fluoro-4-hydroxy-phenyl)-butyric acid (588-25-0)

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃

2: KOH; diethylene glycol; N₂H₄+H₂O

With potassium hydroxide; aluminium trichloride; hydrazine hydrate; diethylene glycol;

DOI:10.1021/jo01353a028

upstream raw materials:

γ-(3-fluoro-4-methoxy)-γ-oxobenzenebutanoic acid

1-fluoro-2-methoxybenzene