4-(Tosyloxy)-2,5-dihydro-3-thiophenecarboxylic acid methyl ester

Base Information

Chemical Name:4-(Tosyloxy)-2,5-dihydro-3-thiophenecarboxylic acid methyl ester
CAS No.:67525-75-1
Molecular Formula:C13H14O5S2
Molecular Weight:314.383
Hs Code.:
DSSTox Substance ID:DTXSID001142651
Nikkaji Number:J1.103.674K

Synonyms:Maybridge1_004853;SCHEMBL17918609;HMS555E13;DTXSID001142651;CCG-55665;AKOS000276857;SR-01000644681-1;4-(Tosyloxy)-2,5-dihydro-3-thiophenecarboxylic acid methyl ester;Methyl 2,5-dihydro-4-[[(4-methylphenyl)sulfonyl]oxy]-3-thiophenecarboxylate;67525-75-1

Suppliers and Price of 4-(Tosyloxy)-2,5-dihydro-3-thiophenecarboxylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(Tosyloxy)-2,5-dihydro-3-thiophenecarboxylic acid methyl ester

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:314.02826589
Heavy Atom Count:20
Complexity:495

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)OC2=C(CSC2)C(=O)OC

Technology Process of 4-(Tosyloxy)-2,5-dihydro-3-thiophenecarboxylic acid methyl ester

There total 2 articles about 4-(Tosyloxy)-2,5-dihydro-3-thiophenecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.5%

: 2689-68-1,99328-39-9
methyl 4-oxotetrahydrothiophene-3-carboxylate

: 98-59-9
p-toluenesulfonyl chloride

: 67525-75-1
methyl 2,5-dihydro-4-(p-toluenesulfonato)thiophene-3-carboxylate

Guidance literature:: With 4-methyl-morpholine; In dichloromethane; for 1.5h; Cooling with ice;

Reference yield:

: 7400-45-5
dimethyl-3-thiaadipate

: 67525-75-1
methyl 2,5-dihydro-4-(p-toluenesulfonato)thiophene-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium methanolate / methanol; toluene / 70 - 110 °C

2: 4-methyl-morpholine / dichloromethane / 1.5 h / Cooling with ice

With 4-methyl-morpholine; lithium methanolate; In methanol; dichloromethane; toluene;