(8S,9S,13S,14S,17S)-4-amino-13-methyl-6,7,8,9,11,12,14,15,16,17-decahy drocyclopenta[a]phenanthrene-3,17-diol

Base Information

Chemical Name:(8S,9S,13S,14S,17S)-4-amino-13-methyl-6,7,8,9,11,12,14,15,16,17-decahy drocyclopenta[a]phenanthrene-3,17-diol
CAS No.:6301-88-8
Molecular Formula:C₁₈H₂₅NO₂
Molecular Weight:287.402
Hs Code.:
Mol file:6301-88-8.mol

Synonyms:Estra-1,3,5(10)-triene-3,17b-diol, 4-amino- (8CI);4-Amino-1,3,5(10)-estratriene-3,17b-diol; 4-Aminoestradiol; NSC 42724

Suppliers and Price of (8S,9S,13S,14S,17S)-4-amino-13-methyl-6,7,8,9,11,12,14,15,16,17-decahy drocyclopenta[a]phenanthrene-3,17-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of (8S,9S,13S,14S,17S)-4-amino-13-methyl-6,7,8,9,11,12,14,15,16,17-decahy drocyclopenta[a]phenanthrene-3,17-diol

Chemical Property:

Vapor Pressure:1.67E-09mmHg at 25°C
Boiling Point:466.5°C at 760 mmHg
Flash Point:235.9°C
PSA：66.48000
Density:1.223g/cm³
LogP:3.77260

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (8S,9S,13S,14S,17S)-4-amino-13-methyl-6,7,8,9,11,12,14,15,16,17-decahy drocyclopenta[a]phenanthrene-3,17-diol

There total 5 articles about (8S,9S,13S,14S,17S)-4-amino-13-methyl-6,7,8,9,11,12,14,15,16,17-decahy drocyclopenta[a]phenanthrene-3,17-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 5976-74-9
4-nitroestrone

: 6301-88-8
4-aminoestra-1,3,5(10)-triene-3,17β-diol

Guidance literature:: With methanol; sodium tetrahydroborate; palladium 10% on activated carbon; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;
DOI:10.1039/d1ra01889b

Reference yield:

: 53-16-7
Estrone

: 6301-88-8
4-aminoestra-1,3,5(10)-triene-3,17β-diol

Guidance literature:: Multi-step reaction with 2 steps

1: nitric acid / dichloromethane / 1 h / 40 °C

2: palladium 10% on activated carbon; sodium tetrahydroborate; methanol / tetrahydrofuran / 0.5 h / 0 - 20 °C

With methanol; sodium tetrahydroborate; palladium 10% on activated carbon; nitric acid; In tetrahydrofuran; dichloromethane;
DOI:10.1039/d1ra01889b